methyl 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylate

Base Information

• Chemical Name: methyl 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylate
• CAS No.: 1020567-95-6
• Molecular Formula: C₃₀H₂₄Cl₂N₂O₄
• Molecular Weight: 547.438
• Mol file: 1020567-95-6.mol

Synonyms:methyl 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylate

Chemical Property of methyl 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylate

There total 3 articles about methyl 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

4-(chloromethyl)-3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazole (700835-81-0) + methyl 7-(4-hydroxyphenyl)quinoline-3-carboxylate (1276656-22-4) → methyl 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylate (1020567-95-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

DOI:10.1016/j.bmcl.2010.12.089

Reference yield:

methyl 7-bromo-3-quinolinecarboxylate (1001756-23-5) → methyl 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylate (1020567-95-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate; palladium diacetate; triphenylphosphine / 1,4-dioxane; water / 1 h / 60 °C

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

With potassium phosphate; palladium diacetate; potassium carbonate; triphenylphosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2010.12.089

Reference yield:

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (269409-70-3) → methyl 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylate (1020567-95-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate; palladium diacetate; triphenylphosphine / 1,4-dioxane; water / 1 h / 60 °C

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

With potassium phosphate; palladium diacetate; potassium carbonate; triphenylphosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2010.12.089

upstream raw materials:

4-(chloromethyl)-3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazole

methyl 7-(4-hydroxyphenyl)quinoline-3-carboxylate

methyl 7-bromo-3-quinolinecarboxylate

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Downstream raw materials:

7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylic acid