7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylic acid

Base Information

• Chemical Name: 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylic acid
• CAS No.: 1020567-77-4
• Molecular Formula: C₂₉H₂₂Cl₂N₂O₄
• Molecular Weight: 533.411
• Mol file: 1020567-77-4.mol

Synonyms:7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylic acid

Chemical Property of 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylic acid

There total 4 articles about 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

methyl 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylate (1020567-95-6) → 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylic acid (1020567-77-4)

Guidance literature:

methyl 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylate; With sodium hydroxide; ethanol; water; In tetrahydrofuran; at 50 ℃; for 16h;

With hydrogenchloride; water; In tetrahydrofuran; ethanol;

Reference yield:

methyl 7-bromo-3-quinolinecarboxylate (1001756-23-5) → 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylic acid (1020567-77-4)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium phosphate; palladium diacetate; triphenylphosphine / 1,4-dioxane; water / 1 h / 60 °C

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

3: sodium hydroxide / tetrahydrofuran; ethanol; water / 16 h / 50 °C

With potassium phosphate; palladium diacetate; potassium carbonate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2010.12.089

Reference yield:

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (269409-70-3) → 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylic acid (1020567-77-4)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium phosphate; palladium diacetate; triphenylphosphine / 1,4-dioxane; water / 1 h / 60 °C

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

3: sodium hydroxide / tetrahydrofuran; ethanol; water / 16 h / 50 °C

With potassium phosphate; palladium diacetate; potassium carbonate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2010.12.089

upstream raw materials:

methyl 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-quinolinecarboxylate

4-(chloromethyl)-3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazole

methyl 7-(4-hydroxyphenyl)quinoline-3-carboxylate

methyl 7-bromo-3-quinolinecarboxylate