N,N'-dibenzyl-1,8-diamino-3,6-dioxaoctane dihydrochloride

Base Information

• Chemical Name: N,N'-dibenzyl-1,8-diamino-3,6-dioxaoctane dihydrochloride
• CAS No.: 75953-69-4
• Molecular Formula: C₂₀H₂₈N₂O₂*2ClH
• Molecular Weight: 401.376
• Mol file: 75953-69-4.mol

Synonyms:N,N'-dibenzyl-1,8-diamino-3,6-dioxaoctane dihydrochloride

Chemical Property of N,N'-dibenzyl-1,8-diamino-3,6-dioxaoctane dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-dibenzyl-1,8-diamino-3,6-dioxaoctane dihydrochloride

There total 2 articles about N,N'-dibenzyl-1,8-diamino-3,6-dioxaoctane dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3,6-dioxa-1,8-diaminooctane (929-59-9,892154-56-2) + benzaldehyde (100-52-7) → N,N'-dibenzyl-1,8-diamino-3,6-dioxaoctane dihydrochloride (75953-69-4)

Guidance literature:

3,6-dioxa-1,8-diaminooctane; benzaldehyde; With sodium sulfate; In dichloromethane; at 20 ℃;

With sodium tetrahydroborate; In acetonitrile; at 0 ℃; Reflux;

With hydrogenchloride; In water; acetonitrile; pH=1; Reflux;

DOI:10.1002/mrc.2316

Reference yield:

1,2-bis-(2-bromo-ethoxy)-ethane (31255-10-4) + N-benzyl-p-toluenesulfonamide (1576-37-0) → N,N'-dibenzyl-1,8-diamino-3,6-dioxaoctane dihydrochloride (75953-69-4)

Guidance literature:

With hydrogenchloride; potassium hydroxide; sodium; Yield given. Multistep reaction; 1. reflux, 10 h, ethanol; 2. reflux, 2-methylbutane-1-ol;

Reference yield: 45.0%

bromoacetic acid tert-butyl ester (5292-43-3) + N,N'-dibenzyl-1,8-diamino-3,6-dioxaoctane dihydrochloride (75953-69-4) → 1,2-bis(N-benzyl-N-tert-butoxycarbonylmethyl-2-aminoethoxy)ethane (1126102-58-6)

Guidance literature:

N,N'-dibenzyl-1,8-diamino-3,6-dioxaoctane dihydrochloride; With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.5h;

bromoacetic acid tert-butyl ester; In 1-methyl-pyrrolidin-2-one; at 20 ℃;

DOI:10.1002/mrc.2316

upstream raw materials:

1,2-bis-(2-bromo-ethoxy)-ethane

N-benzyl-p-toluenesulfonamide

3,6-dioxa-1,8-diaminooctane

benzaldehyde

Downstream raw materials:

3,12-dibenzyl-3,12-diaza-6,9,17-trioxabicyclo<12,2,1>heptadeca-14,16-diene-2,13-dione

7,16-dibenzyl-2,3-dimethyl-7,16-diaza-1,4,10,13-tetraoxacyclopentadecane-6,17-dione

1,2-bis(N-benzyl-N-tert-butoxycarbonylmethyl-2-aminoethoxy)ethane