N-Cbz-O-MOM-ΔTyr-OEt

Base Information

• Chemical Name: N-Cbz-O-MOM-ΔTyr-OEt
• CAS No.: 108158-13-0
• Molecular Formula: C₂₁H₂₃NO₆
• Molecular Weight: 385.417
• Mol file: 108158-13-0.mol

Synonyms:N-Cbz-O-MOM-ΔTyr-OEt

Chemical Property of N-Cbz-O-MOM-ΔTyr-OEt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Cbz-O-MOM-ΔTyr-OEt

There total 3 articles about N-Cbz-O-MOM-ΔTyr-OEt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

benzyl chloroformate (501-53-1,94274-21-2) + (Z)-2-Amino-3-(4-methoxymethoxy-phenyl)-acrylic acid ethyl ester (108158-12-9) → N-Cbz-O-MOM-ΔTyr-OEt (108158-13-0)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; for 24h;

DOI:10.3987/R-1986-06-1561

Reference yield:

4-methoxymethoxy-benzaldehyde (6515-21-5) → N-Cbz-O-MOM-ΔTyr-OEt (108158-13-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 57 percent / EtONa / ethanol / 4 h / 0 °C

2: 95 percent / Al(Hg) / diethyl ether

3: 60 percent / NaOH, n-Bu₄N*HSO₄ / CH₂Cl₂ / 24 h

With sodium hydroxide; aluminum amalgam; sodium ethanolate; tetra(n-butyl)ammonium hydrogensulfate; In diethyl ether; ethanol; dichloromethane;

DOI:10.3987/R-1986-06-1561

Reference yield:

ethyl 2-azido-(p-methoxymethoxy)cinnamate (108158-11-8) → N-Cbz-O-MOM-ΔTyr-OEt (108158-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / Al(Hg) / diethyl ether

2: 60 percent / NaOH, n-Bu₄N*HSO₄ / CH₂Cl₂ / 24 h

With sodium hydroxide; aluminum amalgam; tetra(n-butyl)ammonium hydrogensulfate; In diethyl ether; dichloromethane;

DOI:10.3987/R-1986-06-1561

upstream raw materials:

benzyl chloroformate

(Z)-2-Amino-3-(4-methoxymethoxy-phenyl)-acrylic acid ethyl ester

4-methoxymethoxy-benzaldehyde

ethyl 2-azido-(p-methoxymethoxy)cinnamate

Downstream raw materials:

N-Cbz-O-MOM-ΔTyr-OH

N-carboxy dehydrotyrosine anhydride