Ethyl 6-(chloromethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

• Chemical Name: Ethyl 6-(chloromethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• CAS No.: 475042-34-3
• Molecular Formula: C₁₄H₁₄Cl₂N₂O₃
• Molecular Weight: 329.183
• European Community (EC) Number: 970-644-3

Synonyms:ethyl 6-(chloromethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate;475042-34-3;Ethyl 6-(chloromethyl)-4-(4-chlorophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate;AKOS021982406;BS-9829;UPCMLD0ENAT5607887:001;EN300-24800;Z203043366;ethyl 2-oxo-6-chloromethyl-4-(4-chlorophenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate;ethyl6-(chloromethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Chemical Property of Ethyl 6-(chloromethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 328.0381477
• Heavy Atom Count: 21
• Complexity: 446

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)C1=C(NC(=O)NC1C2=CC=C(C=C2)Cl)CCl

Technology Process of Ethyl 6-(chloromethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 1 articles about Ethyl 6-(chloromethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl (2-chloroaceto)acetate (638-07-3) + 4-chlorobenzaldehyde (104-88-1) + urea (57-13-6) → ethyl 6-(chloromethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (475042-34-3)

Guidance literature:

at 80 ℃; for 1h;

DOI:10.1039/d0nj05697a

Reference yield: 90.0%

4-Chloro-3-methylphenol (59-50-7) + ethyl 6-(chloromethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (475042-34-3) → ethyl 6-((4-chloro-3-methylphenoxy)methyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:

With potassium carbonate; In acetonitrile; at 80 ℃;

DOI:10.1016/j.bioorg.2019.103317

Reference yield: 90.0%

ethyl 6-(chloromethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (475042-34-3) + 3-chloro-4-fluorophenol (2613-23-2) → ethyl6-((3-chloro-4-fluorophenoxy)methyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:

With potassium carbonate; In acetonitrile; at 80 ℃;

DOI:10.1016/j.bioorg.2019.103317

upstream raw materials:

ethyl (2-chloroaceto)acetate

4-chlorobenzaldehyde

urea

Downstream raw materials:

ethyl 6-(azidomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 475042-34-3 ethyl 6-(chloromethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send