Technology Process of 3-{4-[(3-{(E,Z)-phenyl[(2,2,2-trifluoroethoxy)imino]methyl}benzyl)amino]phenyl}propanoic acid
There total 4 articles about 3-{4-[(3-{(E,Z)-phenyl[(2,2,2-trifluoroethoxy)imino]methyl}benzyl)amino]phenyl}propanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-(4-aminophenyl)propionic acid;
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.25h;
(E,Z)-1-[3-(bromomethyl)phenyl]-1-phenyl-N-(2,2,2-trifluoroethoxy)methanimine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydroxylamine hydrochloride; sodium acetate; acetic acid / 3 h / 80 °C
2.1: sodium hydride / N,N-dimethyl-formamide; benzene / 0.5 h / 0 °C
2.2: 1 h / 0 - 20 °C
3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 8 h / 75 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C
4.2: 2 h / 20 °C
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; sodium acetate; sodium hydride; potassium carbonate; acetic acid;
In
tetrachloromethane; N,N-dimethyl-formamide; benzene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; benzene / 0.5 h / 0 °C
1.2: 1 h / 0 - 20 °C
2.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 8 h / 75 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C
3.2: 2 h / 20 °C
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; potassium carbonate;
In
tetrachloromethane; N,N-dimethyl-formamide; benzene;
