Technology Process of methyl 4-acetoxy-5-benzyloxy-6-methyl-1-oxynicotinate
There total 9 articles about methyl 4-acetoxy-5-benzyloxy-6-methyl-1-oxynicotinate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
chloroform;
at 20 ℃;
for 1.5h;
Inert atmosphere;
Cooling with ice;
DOI:10.1021/jm301550c
- Guidance literature:
-
Multi-step reaction with 4 steps
1: N-Bromosuccinimide / acetonitrile / 1.5 h / 20 °C / Inert atmosphere
2: palladium diacetate; triethylamine; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 18.5 h / 20 - 80 °C / Inert atmosphere
3: 0.67 h / 130 °C / Inert atmosphere
4: 3-chloro-benzenecarboperoxoic acid / chloroform / 1.5 h / 20 °C / Inert atmosphere; Cooling with ice
With
N-Bromosuccinimide; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm301550c
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate / N,N-dimethyl-formamide / 1.25 h / 80 °C / Inert atmosphere
2: ammonia; sodium hydroxide / ethanol / 1 h / 90 °C / Inert atmosphere
3: N-Bromosuccinimide / acetonitrile / 1.5 h / 20 °C / Inert atmosphere
4: palladium diacetate; triethylamine; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 18.5 h / 20 - 80 °C / Inert atmosphere
5: 0.67 h / 130 °C / Inert atmosphere
6: 3-chloro-benzenecarboperoxoic acid / chloroform / 1.5 h / 20 °C / Inert atmosphere; Cooling with ice
With
N-Bromosuccinimide; 1,3-bis-(diphenylphosphino)propane; ammonia; palladium diacetate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide;
In
ethanol; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm301550c
