[(2S,3R,4R,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-6-methyl-2-phenylsulfanyl-tetrahydro-pyran-3-yl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:[(2S,3R,4R,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-6-methyl-2-phenylsulfanyl-tetrahydro-pyran-3-yl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester
CAS No.:316792-09-3
Molecular Formula:C₃₄H₄₃NO₅SSi
Molecular Weight:605.871
Hs Code.:

[(2S,3R,4R,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-6-methyl-2-phenylsulfanyl-tetrahydro-pyran-3-yl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

Synonyms:[(2S,3R,4R,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-6-methyl-2-phenylsulfanyl-tetrahydro-pyran-3-yl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of [(2S,3R,4R,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-6-methyl-2-phenylsulfanyl-tetrahydro-pyran-3-yl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of [(2S,3R,4R,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-6-methyl-2-phenylsulfanyl-tetrahydro-pyran-3-yl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 5 articles about [(2S,3R,4R,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-6-methyl-2-phenylsulfanyl-tetrahydro-pyran-3-yl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 108-98-5
thiophenol

: 316792-08-2
[2-benzyloxy-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-tetrahydro-pyran-3-yl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

: 316792-09-3
[(2S,3R,4R,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-6-methyl-2-phenylsulfanyl-tetrahydro-pyran-3-yl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With boron trifluoride diethyl etherate; at 20 ℃; for 5h;
DOI:10.1002/1521-3773(20001016)39:20<3656::AID-ANIE3656>3.0.CO;2-O

Reference yield:

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 316792-09-3
[(2S,3R,4R,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-6-methyl-2-phenylsulfanyl-tetrahydro-pyran-3-yl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / aq. K₂CO₃ / tetrahydrofuran / 0.5 h / 20 °C

2: 68 percent / BF₃*OEt₂ / 5 h / 20 °C

With boron trifluoride diethyl etherate; potassium carbonate; In tetrahydrofuran; 1: Acylation / 2: Substitution;
DOI:10.1002/1521-3773(20001016)39:20<3656::AID-ANIE3656>3.0.CO;2-O

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 316792-09-3
[(2S,3R,4R,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-6-methyl-2-phenylsulfanyl-tetrahydro-pyran-3-yl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / 2,6-lutidine / 16 h / 40 °C

2: 95 percent / aq. K₂CO₃ / tetrahydrofuran / 0.5 h / 20 °C

3: 68 percent / BF₃*OEt₂ / 5 h / 20 °C

With 2,6-dimethylpyridine; boron trifluoride diethyl etherate; potassium carbonate; In tetrahydrofuran; 1: Etherification / 2: Acylation / 3: Substitution;
DOI:10.1002/1521-3773(20001016)39:20<3656::AID-ANIE3656>3.0.CO;2-O