5-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-1,3.4-thiadiazol-2-amine

Base Information

Chemical Name:5-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-1,3.4-thiadiazol-2-amine
CAS No.:1094052-01-3
Molecular Formula:C₂₅H₂₆N₄OS
Molecular Weight:430.574
Hs Code.:

Synonyms:5-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-1,3.4-thiadiazol-2-amine

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Chemical Property of 5-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-1,3.4-thiadiazol-2-amine

Chemical Property:

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Technology Process of 5-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-1,3.4-thiadiazol-2-amine

There total 11 articles about 5-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-1,3.4-thiadiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1094052-00-2
2-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}benzoyl)hydrazinecarbothioamide

: 1094052-01-3
5-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-1,3.4-thiadiazol-2-amine

Guidance literature:: With methanesulfonic acid; In toluene; Reflux;

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1094052-01-3
5-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-1,3.4-thiadiazol-2-amine

Guidance literature:: Multi-step reaction with 10 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0 °C

2.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 1 h / 50 °C

2.2: 20 °C

2.3: 0.5 h

3.1: iodine; magnesium; lithium chloride / tetrahydrofuran / 50 °C

3.2: 0 - 20 °C

4.1: sodium carbonate / N,N-dimethyl-formamide

5.1: hydrogen / palladium hydroxide, 20 wt% on carbon / ethanol / 72 h / 760.05 Torr

6.1: Chiralpak_.(R). AD / methanol / Resolution of racemate

7.1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide

8.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 1 h / 55 °C

8.2: 20 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

10.1: methanesulfonic acid / toluene / Reflux

With methanesulfonic acid; lithium hydroxide monohydrate; water; hydrogen; iodine; sodium carbonate; caesium carbonate; magnesium; N-ethyl-N,N-diisopropylamine; HATU; potassium iodide; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; palladium hydroxide, 20 wt% on carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 131379-16-3
4-(ethoxycarbonyl)phenylzinc iodide

: 1094052-01-3
5-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-1,3.4-thiadiazol-2-amine

Guidance literature:: Multi-step reaction with 10 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0 °C

2.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 1 h / 50 °C

2.2: 20 °C

2.3: 0.5 h

3.1: iodine; magnesium; lithium chloride / tetrahydrofuran / 50 °C

3.2: 0 - 20 °C

4.1: sodium carbonate / N,N-dimethyl-formamide

5.1: hydrogen / palladium hydroxide, 20 wt% on carbon / ethanol / 72 h / 760.05 Torr

6.1: Chiralpak_.(R). AD / methanol / Resolution of racemate

7.1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide

8.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 1 h / 55 °C

8.2: 20 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

10.1: methanesulfonic acid / toluene / Reflux

With methanesulfonic acid; lithium hydroxide monohydrate; water; hydrogen; iodine; sodium carbonate; caesium carbonate; magnesium; N-ethyl-N,N-diisopropylamine; HATU; potassium iodide; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; palladium hydroxide, 20 wt% on carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; toluene;