phenylacetyl-aza-allylglycinyl-(2S)-prolyl-(2S)-(3-pyridyl)alaninyl-(3S)-β-homophenylalanine

Base Information

Chemical Name:phenylacetyl-aza-allylglycinyl-(2S)-prolyl-(2S)-(3-pyridyl)alaninyl-(3S)-β-homophenylalanine
CAS No.:1329063-29-7
Molecular Formula:C₃₅H₄₀N₆O₆
Molecular Weight:640.739
Hs Code.:

Synonyms:phenylacetyl-aza-allylglycinyl-(2S)-prolyl-(2S)-(3-pyridyl)alaninyl-(3S)-β-homophenylalanine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of phenylacetyl-aza-allylglycinyl-(2S)-prolyl-(2S)-(3-pyridyl)alaninyl-(3S)-β-homophenylalanine

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Technology Process of phenylacetyl-aza-allylglycinyl-(2S)-prolyl-(2S)-(3-pyridyl)alaninyl-(3S)-β-homophenylalanine

There total 11 articles about phenylacetyl-aza-allylglycinyl-(2S)-prolyl-(2S)-(3-pyridyl)alaninyl-(3S)-β-homophenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1329063-73-1
C₄₂H₄₆N₆O₆

: 1329063-29-7
phenylacetyl-aza-allylglycinyl-(2S)-prolyl-(2S)-(3-pyridyl)alaninyl-(3S)-β-homophenylalanine

Guidance literature:: C₄₂H₄₆N₆O₆; With lithium hydroxide; In 1,4-dioxane; at 0 ℃; Inert atmosphere;

With hydrogenchloride; In water; pH=5; Inert atmosphere;
DOI:10.1021/jm200608k

Reference yield:

: 1234782-88-7
benzhydrylidene aza-allylglycinyl-proline tert-butyl ester

: 1329063-29-7
phenylacetyl-aza-allylglycinyl-(2S)-prolyl-(2S)-(3-pyridyl)alaninyl-(3S)-β-homophenylalanine

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine; hydroxylamine hydrochloride / 60 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / ethyl acetate / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

4.1: 4-methyl-morpholine / tetrahydrofuran / 0.25 h / -15 °C / Inert atmosphere

5.1: 4-methyl-morpholine / tetrahydrofuran; ethyl acetate / -15 °C / Inert atmosphere

6.1: lithium hydroxide / 1,4-dioxane / 0 °C / Inert atmosphere

6.2: pH 5 / Inert atmosphere

With 4-methyl-morpholine; pyridine; hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate;
DOI:10.1021/jm200608k

Reference yield:

: 1329063-33-3
(3S)-β-homophenylalanine benzyl ester hydrochloride

: 1329063-29-7
phenylacetyl-aza-allylglycinyl-(2S)-prolyl-(2S)-(3-pyridyl)alaninyl-(3S)-β-homophenylalanine

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

1.2: 3 h / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

2.2: 1 h / Inert atmosphere

3.1: 4-methyl-morpholine / tetrahydrofuran; ethyl acetate / -15 °C / Inert atmosphere

4.1: lithium hydroxide / 1,4-dioxane / 0 °C / Inert atmosphere

4.2: pH 5 / Inert atmosphere

With 4-methyl-morpholine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate;
DOI:10.1021/jm200608k