4-[(3,4,5-Trimethoxyphenyl)methyl]-2-piperazinemethanol

Base Information

Chemical Name:4-[(3,4,5-Trimethoxyphenyl)methyl]-2-piperazinemethanol
CAS No.:129799-18-4
Molecular Formula:C₁₅H₂₄N₂O₄
Molecular Weight:296.367
Hs Code.:
DSSTox Substance ID:DTXSID601206451

Synonyms:SCHEMBL9782036;DTXSID601206451;4-[(3,4,5-Trimethoxyphenyl)methyl]-2-piperazinemethanol;129799-18-4

Suppliers and Price of 4-[(3,4,5-Trimethoxyphenyl)methyl]-2-piperazinemethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[(3,4,5-Trimethoxyphenyl)methyl]-2-piperazinemethanol

Chemical Property:

XLogP3:0.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:296.17360725
Heavy Atom Count:21
Complexity:291

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)CN2CCNC(C2)CO

Technology Process of 4-[(3,4,5-Trimethoxyphenyl)methyl]-2-piperazinemethanol

There total 3 articles about 4-[(3,4,5-Trimethoxyphenyl)methyl]-2-piperazinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 129798-93-2
ethyl 4-(3,4,5-trimethoxybenzoyl)piperazine-2-carboxylate

: 129799-18-4
4-(3,4,5-trimethoxybenzyl)-piperazine-2-methanol

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; for 1h; Ambient temperature;
DOI:10.1248/cpb.42.551

Reference yield:

: 89941-07-1
ethyl 2-piperazinecarboxylate

: 129799-18-4
4-(3,4,5-trimethoxybenzyl)-piperazine-2-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: 34 percent / sodium bis(2-methoxyethoxy)aluminum hydride / toluene / 1 h / Ambient temperature

With triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In dichloromethane; toluene;
DOI:10.1248/cpb.42.551

Reference yield:

: 4521-61-3
3,4,5-Trimethoxybenzoyl chloride

: 129799-18-4
4-(3,4,5-trimethoxybenzyl)-piperazine-2-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: 34 percent / sodium bis(2-methoxyethoxy)aluminum hydride / toluene / 1 h / Ambient temperature

With triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In dichloromethane; toluene;
DOI:10.1248/cpb.42.551