tert-butyl tert-butoxycarbonyl(3-(3-(4-(((tert-butoxycarbonyl)(tetrahydro-2H-pyran-4-yl)amino)methyl)phenyl)isoxazol-5-yl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate

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Chemical Name:tert-butyl tert-butoxycarbonyl(3-(3-(4-(((tert-butoxycarbonyl)(tetrahydro-2H-pyran-4-yl)amino)methyl)phenyl)isoxazol-5-yl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate
CAS No.:1428935-58-3
Molecular Formula:C₄₃H₅₅N₅O₁₀S
Molecular Weight:834.003
Hs Code.:

tert-butyl tert-butoxycarbonyl(3-(3-(4-(((tert-butoxycarbonyl)(tetrahydro-2H-pyran-4-yl)amino)methyl)phenyl)isoxazol-5-yl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate

Synonyms:tert-butyl tert-butoxycarbonyl(3-(3-(4-(((tert-butoxycarbonyl)(tetrahydro-2H-pyran-4-yl)amino)methyl)phenyl)isoxazol-5-yl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate

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Chemical Property of tert-butyl tert-butoxycarbonyl(3-(3-(4-(((tert-butoxycarbonyl)(tetrahydro-2H-pyran-4-yl)amino)methyl)phenyl)isoxazol-5-yl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate

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Technology Process of tert-butyl tert-butoxycarbonyl(3-(3-(4-(((tert-butoxycarbonyl)(tetrahydro-2H-pyran-4-yl)amino)methyl)phenyl)isoxazol-5-yl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate

There total 11 articles about tert-butyl tert-butoxycarbonyl(3-(3-(4-(((tert-butoxycarbonyl)(tetrahydro-2H-pyran-4-yl)amino)methyl)phenyl)isoxazol-5-yl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 850567-98-5
4-(isopropylsulfonyl)phenylboronic acid

: 1402390-91-3
tert-butyl (5-bromo-3-(3-(4-(((tert-butoxycarbonyl)(tetrahydro-2H-pyran-4-yl)amino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)(tert-butoxycarbonyl)carbamate

: 1428935-58-3
tert-butyl tert-butoxycarbonyl(3-(3-(4-(((tert-butoxycarbonyl)(tetrahydro-2H-pyran-4-yl)amino)methyl)phenyl)isoxazol-5-yl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate

Guidance literature:: With dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; potassium carbonate; In water; toluene; at 70 ℃; Inert atmosphere;

Reference yield:

: 875781-41-2
5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine

: 1428935-58-3
tert-butyl tert-butoxycarbonyl(3-(3-(4-(((tert-butoxycarbonyl)(tetrahydro-2H-pyran-4-yl)amino)methyl)phenyl)isoxazol-5-yl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / dichloromethane / 2 h / 20 °C

2.1: potassium carbonate / water; ethanol; ethyl acetate / 3 h

3.1: triethylamine / dichloromethane / Cooling with ice

3.2: 20 °C

4.1: potassium carbonate; dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium / water; toluene / 70 °C / Inert atmosphere

With dmap; dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; potassium carbonate; triethylamine; In ethanol; dichloromethane; water; ethyl acetate; toluene;

Reference yield:

: 81172-89-6
terephthalaldehyde mono(diethylacetal)

: 1428935-58-3
tert-butyl tert-butoxycarbonyl(3-(3-(4-(((tert-butoxycarbonyl)(tetrahydro-2H-pyran-4-yl)amino)methyl)phenyl)isoxazol-5-yl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / methanol / 0.83 h / 20 - 25 °C

1.2: 1 h / 25 °C

2.1: triethylamine / dichloromethane / 12 - 20 h / 20 - 25 °C

3.1: hydroxylamine hydrochloride / tetrahydrofuran; water / 16 - 20 h / 20 - 25 °C

4.1: N-chloro-succinimide / Isopropyl acetate / 20 °C

5.1: triethylamine / dichloromethane / 20 - 30 °C

6.1: potassium carbonate; dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium / water; toluene / 70 °C / Inert atmosphere

With N-chloro-succinimide; dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; hydroxylamine hydrochloride; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; Isopropyl acetate; water; toluene;