3-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzyl acetate fumarate

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Chemical Name:3-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzyl acetate fumarate
CAS No.:1055305-39-9
Molecular Formula:C₄H₄O₄*C₂₀H₁₉F₂N₃O₄S
Molecular Weight:551.525
Hs Code.:

Synonyms:3-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzyl acetate fumarate

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Chemical Property of 3-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzyl acetate fumarate

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Technology Process of 3-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzyl acetate fumarate

There total 15 articles about 3-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzyl acetate fumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1055307-04-4
tert-butyl [(4-fluoro-5-(2-fluoropyridin-3-yl)-1-{[3-(hydroxymethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methyl]methylcarbamate

: 141-78-6
ethyl acetate

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 1055305-39-9
3-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzyl acetate fumarate

Guidance literature:: tert-butyl [(4-fluoro-5-(2-fluoropyridin-3-yl)-1-{[3-(hydroxymethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methyl]methylcarbamate; ethyl acetate; With hydrogenchloride; methanol; isopropyl alcohol; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In water;

(2E)-but-2-enedioic acid; In ethanol; ethyl acetate;

Reference yield:

: 3-(4,4-difluoro-3-methylidene-3,4-dihydro-2H-pyrrol-5-yl)-2-fluoropyridine

: 1055305-39-9
3-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzyl acetate fumarate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / tetrahydrofuran / 18 h / 0 - 60 °C

1.2: 1 h / 0 °C

2.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

2.2: 0.17 h / 0 °C

2.3: 0.25 h / 0 °C

3.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 0.25 h / 0 °C

3.2: 16 h / 65 °C

3.3: 0.17 h / 20 °C

4.1: tetrahydrofuran / 0.08 h / 20 °C

5.1: sodium hydroxide; water; isopropyl alcohol / tetrahydrofuran / 18 h / 0 - 20 °C

6.1: 15-crown-5; sodium hydride / tetrahydrofuran / 1 h / 0 °C

7.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h

8.1: dimethylsulfide borane complex / tetrahydrofuran; toluene / 24 h / 20 °C

9.1: hydrogenchloride; methanol; isopropyl alcohol / 2 h / 20 °C

With hydrogenchloride; methanol; sodium hydroxide; 15-crown-5; carbonochloridic acid 1-chloro-ethyl ester; dimethylsulfide borane complex; water; hydrogen; sodium hydride; isopropyl alcohol; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; toluene;

Reference yield:

: 1055306-63-2
tert-butyl (4RS)-4-(bromomethyl)-3,3-difluoro-2-oxopyrrolidine-1-carboxylate

: 1055305-39-9
3-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzyl acetate fumarate

Guidance literature:: Multi-step reaction with 12 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1.25 h / 0 - 20 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2.75 h / -78 °C

2.2: 3 h / -78 °C

3.1: hydrogenchloride; water; acetic acid / 1 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 18 h / 0 - 60 °C

4.2: 1 h / 0 °C

5.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

5.2: 0.17 h / 0 °C

5.3: 0.25 h / 0 °C

6.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 0.25 h / 0 °C

6.2: 16 h / 65 °C

6.3: 0.17 h / 20 °C

7.1: tetrahydrofuran / 0.08 h / 20 °C

8.1: sodium hydroxide; water; isopropyl alcohol / tetrahydrofuran / 18 h / 0 - 20 °C

9.1: 15-crown-5; sodium hydride / tetrahydrofuran / 1 h / 0 °C

10.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h

11.1: dimethylsulfide borane complex / tetrahydrofuran; toluene / 24 h / 20 °C

12.1: hydrogenchloride; methanol; isopropyl alcohol / 2 h / 20 °C

With hydrogenchloride; methanol; sodium hydroxide; n-butyllithium; 15-crown-5; carbonochloridic acid 1-chloro-ethyl ester; dimethylsulfide borane complex; water; hydrogen; sodium hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropylamine; isopropyl alcohol; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; toluene;