tert-butyl [(4-fluoro-5-(2-fluoropyridin-3-yl)-1-{[3-(hydroxymethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methyl]methylcarbamate

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Chemical Name:tert-butyl [(4-fluoro-5-(2-fluoropyridin-3-yl)-1-{[3-(hydroxymethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methyl]methylcarbamate
CAS No.:1055307-04-4
Molecular Formula:C₂₃H₂₅F₂N₃O₅S
Molecular Weight:493.531
Hs Code.:

Synonyms:tert-butyl [(4-fluoro-5-(2-fluoropyridin-3-yl)-1-{[3-(hydroxymethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methyl]methylcarbamate

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Chemical Property of tert-butyl [(4-fluoro-5-(2-fluoropyridin-3-yl)-1-{[3-(hydroxymethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methyl]methylcarbamate

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Technology Process of tert-butyl [(4-fluoro-5-(2-fluoropyridin-3-yl)-1-{[3-(hydroxymethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methyl]methylcarbamate

There total 16 articles about tert-butyl [(4-fluoro-5-(2-fluoropyridin-3-yl)-1-{[3-(hydroxymethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methyl]methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1055307-02-2
3-{[4-{[(tert-butoxycarbonyl)(methyl)amino]methyl}-3-fluoro-2-(2-fluoropyridin-3-yl)-1H-pyrrol-1-yl]sulfonyl}benzoic acid

: 1055307-04-4
tert-butyl [(4-fluoro-5-(2-fluoropyridin-3-yl)-1-{[3-(hydroxymethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methyl]methylcarbamate

Guidance literature:: 3-{[4-{[(tert-butoxycarbonyl)(methyl)amino]methyl}-3-fluoro-2-(2-fluoropyridin-3-yl)-1H-pyrrol-1-yl]sulfonyl}benzoic acid; With dimethylsulfide borane complex; In tetrahydrofuran; toluene; at 20 ℃; for 24h;

With water; In tetrahydrofuran; toluene;

Reference yield:

: 3-(4,4-difluoro-3-methylidene-3,4-dihydro-2H-pyrrol-5-yl)-2-fluoropyridine

: 1055307-04-4
tert-butyl [(4-fluoro-5-(2-fluoropyridin-3-yl)-1-{[3-(hydroxymethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methyl]methylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / tetrahydrofuran / 18 h / 0 - 60 °C

1.2: 1 h / 0 °C

2.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

2.2: 0.17 h / 0 °C

2.3: 0.25 h / 0 °C

3.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 0.25 h / 0 °C

3.2: 16 h / 65 °C

3.3: 0.17 h / 20 °C

4.1: tetrahydrofuran / 0.08 h / 20 °C

5.1: sodium hydroxide; water; isopropyl alcohol / tetrahydrofuran / 18 h / 0 - 20 °C

6.1: 15-crown-5; sodium hydride / tetrahydrofuran / 1 h / 0 °C

7.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h

8.1: dimethylsulfide borane complex / tetrahydrofuran; toluene / 24 h / 20 °C

With sodium hydroxide; 15-crown-5; carbonochloridic acid 1-chloro-ethyl ester; dimethylsulfide borane complex; water; hydrogen; sodium hydride; isopropyl alcohol; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; toluene;

Reference yield:

: 1055306-64-3
tert-butyl 3,3-difluoro-4-methylidene-2-oxopyrrolidine-1-carboxylate

: 1055307-04-4
tert-butyl [(4-fluoro-5-(2-fluoropyridin-3-yl)-1-{[3-(hydroxymethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methyl]methylcarbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2.75 h / -78 °C

1.2: 3 h / -78 °C

2.1: hydrogenchloride; water; acetic acid / 1 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 18 h / 0 - 60 °C

3.2: 1 h / 0 °C

4.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

4.2: 0.17 h / 0 °C

4.3: 0.25 h / 0 °C

5.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 0.25 h / 0 °C

5.2: 16 h / 65 °C

5.3: 0.17 h / 20 °C

6.1: tetrahydrofuran / 0.08 h / 20 °C

7.1: sodium hydroxide; water; isopropyl alcohol / tetrahydrofuran / 18 h / 0 - 20 °C

8.1: 15-crown-5; sodium hydride / tetrahydrofuran / 1 h / 0 °C

9.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h

10.1: dimethylsulfide borane complex / tetrahydrofuran; toluene / 24 h / 20 °C

With hydrogenchloride; sodium hydroxide; n-butyllithium; 15-crown-5; carbonochloridic acid 1-chloro-ethyl ester; dimethylsulfide borane complex; water; hydrogen; sodium hydride; acetic acid; diisopropylamine; isopropyl alcohol; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; toluene;