4-Diethylamino-piperidine

Base Information

• Chemical Name: 4-Diethylamino-piperidine
• CAS No.: 143300-64-5
• Molecular Formula: C9H20N2
• Molecular Weight: 156.271
• Hs Code.: 29339900
• European Community (EC) Number: 673-562-3
• DSSTox Substance ID: DTXSID00374233
• Wikidata: Q82162750
• Mol file: 143300-64-5.mol

Synonyms:4-Diethylamino-piperidine;143300-64-5;N,N-diethylpiperidin-4-amine;4-(diethylamino)piperidine;4-Piperidinamine, N,N-diethyl-;4-diethylaminopiperidine;diethyl-piperidin-4-yl-amine;MFCD04971982;N,N-diethyl-4-piperidinamine;4-diethylamino piperidine;diethyl-4-piperidinylamine;Diethylpiperidin-4-ylamine;SCHEMBL255044;4-Piperidinamine,N,N-diethyl-;4-(N,N-diethylamino)piperidine;DTXSID00374233;CHEBI:191150;OUXRMEUJNPVXMM-UHFFFAOYSA-N;AKOS000197202;AM85299;PS-3225;SB18444;SY002770;FT-0653100;EN300-44137;J-007794;Z317268610

Chemical Property of 4-Diethylamino-piperidine

Chemical Property:

• Vapor Pressure: 0.16mmHg at 25°C
• Refractive Index: 1.478
• Boiling Point: 213.933 °C at 760 mmHg
• PKA: 10.32±0.20(Predicted)
• Flash Point: 71.283 °C
• PSA: 15.27000
• Density: 0.899 g/cm³
• LogP: 1.40900
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 156.162648646
• Heavy Atom Count: 11
• Complexity: 93.7

Purity/Quality:

97% ^*data from raw suppliers

4-Diethylamino-piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)C1CCNCC1

Technology Process of 4-Diethylamino-piperidine

There total 7 articles about 4-Diethylamino-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-(diethylamino)piperidine dihydrochloride (50534-25-3) → N,N-diethylpiperidin-4-amine (143300-64-5)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 0.5h;

Reference yield:

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) + diethylamine (109-89-7) → N,N-diethylpiperidin-4-amine (143300-64-5)

Guidance literature:

benzyl 4-oxo-1-piperidinecarboxylate; diethylamine; With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 16h;

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 16h;

Reference yield:

C17H26N2O2 → N,N-diethylpiperidin-4-amine (143300-64-5)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 16h;

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

4-(diethylamino)piperidine dihydrochloride

benzyl 4-oxo-1-piperidinecarboxylate

diethylamine

Downstream raw materials:

(E)-1-(4-Diethylamino-piperidin-1-yl)-3-[4-(2-ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-phenyl]-propenone