(R)-N-[4-Ethylsulphanyl-3-iodo-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Base Information

Chemical Name:(R)-N-[4-Ethylsulphanyl-3-iodo-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide
CAS No.:329926-69-4
Molecular Formula:C₁₂H₁₂ClF₃INO₂S
Molecular Weight:453.651
Hs Code.:

Synonyms:(R)-N-[4-Ethylsulphanyl-3-iodo-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

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Chemical Property of (R)-N-[4-Ethylsulphanyl-3-iodo-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

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Technology Process of (R)-N-[4-Ethylsulphanyl-3-iodo-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

There total 5 articles about (R)-N-[4-Ethylsulphanyl-3-iodo-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 329926-70-7
(R)-N-[4-mercapto-3-iodo-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

: 75-03-6
ethyl iodide

: 329926-69-4
(R)-N-[4-Ethylsulphanyl-3-iodo-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Guidance literature:: With sodium methylate; In tetrahydrofuran; for 1h; Heating / reflux;

Reference yield:

: 329901-81-7
(R)-N-(3-nitro-2-chlorophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

: 329926-69-4
(R)-N-[4-Ethylsulphanyl-3-iodo-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 °C

2.1: sulfuric acid; sodium nitrite / water / 1.2 h / 20 °C

2.2: 2.5 h / 100 °C

3.1: chlorosulfonic acid / 4 h / 0 - 80 °C

4.1: N,N-dimethyl-formamide; triphenylphosphine / dichloromethane / 0.75 h / 0 - 20 °C

5.1: sodium methylate / tetrahydrofuran / 1 h / Heating / reflux

With chlorosulfonic acid; sulfuric acid; hydrogen; sodium methylate; N,N-dimethyl-formamide; triphenylphosphine; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; water; ethyl acetate;

Reference yield:

: 329901-80-6
(R)-N-[3-amino-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

: 329926-69-4
(R)-N-[4-Ethylsulphanyl-3-iodo-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid; sodium nitrite / water / 1.2 h / 20 °C

1.2: 2.5 h / 100 °C

2.1: chlorosulfonic acid / 4 h / 0 - 80 °C

3.1: N,N-dimethyl-formamide; triphenylphosphine / dichloromethane / 0.75 h / 0 - 20 °C

4.1: sodium methylate / tetrahydrofuran / 1 h / Heating / reflux

With chlorosulfonic acid; sulfuric acid; sodium methylate; N,N-dimethyl-formamide; triphenylphosphine; sodium nitrite; In tetrahydrofuran; dichloromethane; water;