3-[(acetoxy)-(2-bromo-3-isopropyl-4,5-dimethoxyphenyl)methyl]-2,4-dimethylphenyl acetate

Base Information

• Chemical Name: 3-[(acetoxy)-(2-bromo-3-isopropyl-4,5-dimethoxyphenyl)methyl]-2,4-dimethylphenyl acetate
• CAS No.: 1357476-77-7
• Molecular Formula: C₂₄H₂₉BrO₆
• Molecular Weight: 493.395
• Mol file: 1357476-77-7.mol

Synonyms:3-[(acetoxy)-(2-bromo-3-isopropyl-4,5-dimethoxyphenyl)methyl]-2,4-dimethylphenyl acetate

Chemical Property of 3-[(acetoxy)-(2-bromo-3-isopropyl-4,5-dimethoxyphenyl)methyl]-2,4-dimethylphenyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[(acetoxy)-(2-bromo-3-isopropyl-4,5-dimethoxyphenyl)methyl]-2,4-dimethylphenyl acetate

There total 8 articles about 3-[(acetoxy)-(2-bromo-3-isopropyl-4,5-dimethoxyphenyl)methyl]-2,4-dimethylphenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

[3-(acetoxy)-2,6-dimethylphenyl](3-isopropyl-4,5-dimethoxyphenyl)methyl acetate (1357476-76-6) → 3-[(acetoxy)-(2-bromo-3-isopropyl-4,5-dimethoxyphenyl)methyl]-2,4-dimethylphenyl acetate (1357476-77-7)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 20 ℃; for 96h;

DOI:10.1080/00397911.2010.518274

Reference yield:

3-[hydroxy(3-isopropenyl-4,5-dimethoxyphenyl)methyl]-2,4-dimethylphenol (1357476-73-3) → 3-[(acetoxy)-(2-bromo-3-isopropyl-4,5-dimethoxyphenyl)methyl]-2,4-dimethylphenyl acetate (1357476-77-7)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr

2: triethylamine / dichloromethane / 14 h / 0 - 20 °C

3: N-Bromosuccinimide / acetonitrile / 96 h / 20 °C

With N-Bromosuccinimide; palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane; acetonitrile;

DOI:10.1080/00397911.2010.518274

Reference yield:

C26H38O4Si (1357476-72-2) → 3-[(acetoxy)-(2-bromo-3-isopropyl-4,5-dimethoxyphenyl)methyl]-2,4-dimethylphenyl acetate (1357476-77-7)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr

3: triethylamine / dichloromethane / 14 h / 0 - 20 °C

4: N-Bromosuccinimide / acetonitrile / 96 h / 20 °C

With N-Bromosuccinimide; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

DOI:10.1080/00397911.2010.518274

upstream raw materials:

C₂₆H₃₈O₄Si

3-[hydroxy(3-isopropenyl-4,5-dimethoxyphenyl)methyl]-2,4-dimethylphenol

3-[hydroxy(3-isopropyl-4,5-dimethoxyphenyl)methyl]-2,4-dimethylphenol

[3-(acetoxy)-2,6-dimethylphenyl](3-isopropyl-4,5-dimethoxyphenyl)methyl acetate

Downstream raw materials:

(2-bromo-3-isopropyl-4,5-dimethoxyphenyl)(3-hydroxy-2,6-dimethylphenyl)methyl acetate

3-[(2-bromo-3-isopropyl-4,5-dimethoxyphenyl)(hydroxy)methyl]-2,4-dimethylphenol

3-[(2-bromo-3-isopropyl-4,5-dimethoxyphenyl)(hydroxy)methyl]-2,4-dimethyl-4-(2,2,2-trifluoroethoxy)cyclohexa-2,5-dien-1-one