2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)quinazoline

Base Information

Chemical Name:2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)quinazoline
CAS No.:1521139-37-6
Molecular Formula:C₂₅H₂₀FN₅O
Molecular Weight:425.465
Hs Code.:

Synonyms:2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)quinazoline

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Chemical Property of 2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)quinazoline

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Technology Process of 2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)quinazoline

There total 8 articles about 2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.5%

: 1301167-65-6
4-[1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenol

: 199114-62-0
2-chloromethyl-3-methyl-4-oxo-3,4-dihydroquinazoline

: 1521139-37-6
2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)quinazoline

Guidance literature:: With caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 3.5h;

Reference yield:

: 171001-06-2
1-(4-(benzyloxy)phenyl)-2-(pyridin-4-yl)ethanone

: 1521139-37-6
2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)quinazoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 1 h / Reflux

1.2: 2 h / Reflux

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

4.1: palladium on activated charcoal; hydrogen / ethanol; ethyl acetate / 18 h / 1900.13 Torr / Autoclave

5.1: caesium carbonate / tetrahydrofuran; N,N-dimethyl-formamide / 3.5 h / 20 °C

With palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1521138-31-7
2-(3-(4-(benzyloxy)phenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl)ethyl methanesulfonate

: 1521139-37-6
2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)quinazoline

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

2: palladium on activated charcoal; hydrogen / ethanol; ethyl acetate / 18 h / 1900.13 Torr / Autoclave

3: caesium carbonate / tetrahydrofuran; N,N-dimethyl-formamide / 3.5 h / 20 °C

With palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;