2-(chloromethyl)-3-methylquinazolin-4(3H)-one

Base Information

Chemical Name:2-(chloromethyl)-3-methylquinazolin-4(3H)-one
CAS No.:199114-62-0
Molecular Formula:C10H9ClN2O
Molecular Weight:208.647
Hs Code.:2933990090
DSSTox Substance ID:DTXSID90429266
Wikidata:Q82242259

Synonyms:2-(chloromethyl)-3-methylquinazolin-4(3H)-one;199114-62-0;2-(chloromethyl)-3-methylquinazolin-4-one;2-(chloromethyl)-3-methyl-3,4-dihydroquinazolin-4-one;SCHEMBL1161498;DTXSID90429266;NDYMABNTFFJQLH-UHFFFAOYSA-N;MFCD07838408;AKOS005260302;BS-21929;EN300-23745;C77592;J-012865;2-chloromethyl-3-methyl-4-oxo-3,4-dihydroquinazoline;2-chloromethyl-3-methyl4-oxo-3,4-dihydroquinazoline;Z164706364;2-(Chloromethyl)-3-methylquinazolin-4(3H)-one, AldrichCPR;(3-Methyl-4-oxo-3,4-dihydro-quinazolin-2-yl)-methyl chloride

Suppliers and Price of 2-(chloromethyl)-3-methylquinazolin-4(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2-(Chloromethyl)-3-methylquinazolin-4(3H)-one 95+%
1g
$ 376.00

Chemenu
2-(chloromethyl)-3-methylquinazolin-4(3H)-one 95%
1g
$ 561.00

American Custom Chemicals Corporation
2-(CHLOROMETHYL)-3-METHYLQUINAZOLIN-4(3H)-ONE 95.00%
2.5G
$ 1473.14

American Custom Chemicals Corporation
2-(CHLOROMETHYL)-3-METHYLQUINAZOLIN-4(3H)-ONE 95.00%
1G
$ 983.52

American Custom Chemicals Corporation
2-(CHLOROMETHYL)-3-METHYLQUINAZOLIN-4(3H)-ONE 95.00%
5G
$ 1928.08

Alichem
2-(Chloromethyl)-3-methylquinazolin-4(3H)-one
25g
$ 3979.80

Alichem
2-(Chloromethyl)-3-methylquinazolin-4(3H)-one
10g
$ 2412.00

Alichem
2-(Chloromethyl)-3-methylquinazolin-4(3H)-one
5g
$ 1704.48

AK Scientific
2-(Chloromethyl)-3-methylquinazolin-4(3h)-one
250mg
$ 291.00

Total 15 raw suppliers

Chemical Property of 2-(chloromethyl)-3-methylquinazolin-4(3H)-one

Chemical Property:

Melting Point:185 °C(Solv: isopropanol (67-63-0))
Boiling Point:337.4±44.0 °C(Predicted)
PKA:0.88±0.70(Predicted)
PSA：34.89000
Density:1.32±0.1 g/cm3(Predicted)
LogP:1.67230
Storage Temp.:2-8°C
XLogP3:1.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:208.0403406
Heavy Atom Count:14
Complexity:277

Purity/Quality:

97% ^*data from raw suppliers

2-(Chloromethyl)-3-methylquinazolin-4(3H)-one 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22-36-52
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(=NC2=CC=CC=C2C1=O)CCl
General Description 2-(Chloromethyl)-3-methylquinazolin-4(3H)-one is a quinazolinone derivative that has been studied as part of a series of 3-methylquinazolinone compounds exhibiting antiproliferative and antitumor activities. It serves as a key intermediate or structural motif in the development of epidermal growth factor receptor (EGFR) inhibitors, demonstrating potential inhibitory effects against tumor cell lines such as A549 (human lung cancer) and other cancer models. The chloromethyl group at the 2-position may contribute to enhanced reactivity or further derivatization, which could influence the compound's biological activity and structure-activity relationships in antitumor applications.

Technology Process of 2-(chloromethyl)-3-methylquinazolin-4(3H)-one

There total 8 articles about 2-(chloromethyl)-3-methylquinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%