199114-62-0

Usage

Uses

Used in Pharmaceutical Industry:
2-(CHLOROMETHYL)-3-METHYLQUINAZOLIN-4(3H)-ONE is used as a potential antitumor agent for its pharmacological activity. The quinazolinone structure is known to have potential as an antitumor agent, and 2-(CHLOROMETHYL)-3-METHYLQUINAZOLIN-4(3H)-ONE may contribute to the development of new cancer treatments.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-(CHLOROMETHYL)-3-METHYLQUINAZOLIN-4(3H)-ONE serves as a subject of study for its potential therapeutic applications. Researchers are exploring its properties and interactions to understand its full range of biological activities and how it can be utilized in drug development.
Used in Drug Discovery:
2-(CHLOROMETHYL)-3-METHYLQUINAZOLIN-4(3H)-ONE is utilized in drug discovery processes to identify new molecular entities with therapeutic potential. Its unique structure and potential biological activities make it a valuable candidate for further research and development into effective pharmaceuticals.

Upstream product

• 53824-91-2 2-ω-chloroacetylamino-N-methylbenzamide 
• 77-78-1 dimethyl sulfate 
• 3817-05-8 2-(chloromethyl)quinazolin-4(3H)-one 
• 79-04-9 chloroacetyl chloride 
• 4141-08-6 2-Amino-N-methylbenzamid 
• 118-48-9 isatoic anhydride 
• 28144-70-9 anthranilic acid amide 
• 21721-78-8 2-ω-chloroacetylaminobenzamide 
• 74-89-5 methylamine 

Downstream Products

• 228871-31-6 2-(4-methylphenyl)aminomethyl-3-methylquinazolin-4(3H)-one 
• 228871-34-9 2-[(4-chloro-phenylamino)-methyl]-3-methyl-3H-quinazolin-4-one 
• 228871-32-7 2-[(4-methoxy-phenylamino)-methyl]-3-methyl-3H-quinazolin-4-one 
• 228871-30-5 2-phenylaminomethyl-3-methyl-4-(3H)-quinazolinone 
• 228871-35-0 2-[(4-bromo-phenylamino)-methyl]-3-methyl-3H-quinazolin-4-one 
• 303223-46-3 2-[3-(2-hydroxymethyl-3-methyl-benzyloxy)-phenoxymethyl]-3-methyl-3H-quinazolin-4-one 
• 1182294-10-5 2-[(4-fluorophenylsulfonyl)methyl]-3-methylquinazolin-4(3H)-one 
• 1182294-08-1 2-[(4-chlorophenylsulfonyl)methyl]-3-methylquinazolin-4(3H)-one 
• 1182294-04-7 3-methyl-2-(phenylsulfonylmethyl)quinazolin-4(3H)-one 
• 1182294-07-0 3-methyl-2-(tosylmethyl)quinazolin-4(3H)-one 
• 1182294-12-7 2-[(4-bromophenylsulfonyl)methyl]-3-methylquinazolin-4(3H)-one 
• 1182294-16-1 3-methyl-2-[(3-nitrophenylsulfonyl)methyl]-3-methylquinazolin-4(3H)-one 
• 1182294-14-9 3-methyl-2-[(4-nitrophenylsulfonyl)methyl]-3-methylquinazolin-4(3H)-one 

Relevant academic research and scientific papers

Synthesis and preliminary structure-activity relationship study of 3-methylquinazolinone derivatives as EGFR inhibitors with enhanced antiproliferative activities against tumour cells

In this paper, a set of 3-methylquniazolinone derivatives were designed, synthesised, and studied the preliminary structure-activity relationship for antiproliferative activities. All target compounds performed significantly inhibitory effects against wil

Design, synthesis, biological activities and 3D-QSAR studies of quinazolinone derivatives containing hydrazone structural units

In this study, three series of quinazolinone derivatives containing hydrazone structures were designed and synthesized. Bioactivity assays indicated that these compounds showed good antitumour activities towards human lung cancer cells (A549) and human pr

Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment

In this paper, a series of novel 3-methyl-quinazolinone derivatives was designed, synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-TK) and three human cancer cell li

Quinazolinone compound containing hydrazone structural unit or stereoisomer, salt or solvate of the quinazolinone compound

The invention relates to a quinazolinone compound containing a hydrazone structural unit, or a stereoisomer, or a salt or a solvate of the quinazolinone compound. The compound has a structure as shownin a general formula (I) shown in the specification. Th

Synthesis of benzoxazolthiolyl and benzthiazolthiolyl fused 3- alkylquinazolin-4(3H)-ones

Condensation of anthranilamide (1) with chloroacetyl chloride for 1 hr at RT gave 2- (2-chloroacetamido) benzamide (2). The latter, on refluxation in acetic acid for 2 hr gave 2-(chloromethyl) quinazolin-4(3H)-one (3). Condensation of 3, independently, with each one of benz [d] oxazole-2-thiol (4a) and benz [d] thiazole-2-thiol (4b), for 3-4 hr, gave 2-((benz [d] oxazol-2-ylthio) methyl) quinazolin-4(3H)-one (5a) and 2-((benz [d] thiazol-2-ylthio) methyl) quinazolin-4(3H)-one (5b) respectively. Each one of the 5a and 5b, independently and selectively, when treated with alkylating agents (i.e. DMS, DES, PhCH2Cl), gave 2-((benz [d] oxazol-2-ylthio) methyl)-3-alkylquinazolin-4(3H)-ones (6a-c) and 2-((benz [d] thiazol-2-ylthio) methyl)-3-alkylquinazolin-4(3H)-ones (6d-f) respectively. The latter 6a-f could also be prepared, alternatively, by condensing chloromethyl-3-alkylquinazolin-4(3H)-one (7a-c) with 4a-b respectively, in good yields.

Microwave-assisted synthesis in aqueous medium of new quinazoline derivatives as anticancer agent precursors

Fast and eco-friendly microwave-irradiated reactions permitting the "green synthesis" of new 2-substituted quinazoline derivatives in aqueous medium via S-alkylation or SRN1 reaction from 2-chloromethyl-3-methylquinazolin-4(3H)-one derivatives with different benzenesulfinic acids and nitronate anions, are reported herein.

Therapeutic uses of tri-aryl acid derivatives

The use of triaryl acid derivatives of formula (I) and their pharmaceutical compositions as PPAR ligand receptor binders. The PPAR ligand receptor binders of this invention are useful as agonists or antagonists of the PPAR receptor.

4-heteryl-β-lactams : A facile synthesis of 1-aryl-4- [isopropylideneamino/methyl-4(3H)-oxoquinazolin-2-yl] azetidin-2-ones

A facile and efficient synthesis of 4-quinazolinonyl-β-lactams 9 and 10 starting from 2-chloromethylquinazolin-4(3H)-ones 1 is reported.