tert-Butyl 2-[6-[3-[4-(diphenylmethoxy)piperidino]-propoxy]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate

Base Information

Chemical Name:tert-Butyl 2-[6-[3-[4-(diphenylmethoxy)piperidino]-propoxy]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate
CAS No.:215529-48-9
Molecular Formula:C₃₅H₄₄N₄O₄
Molecular Weight:584.759
Hs Code.:

Synonyms:tert-Butyl 2-[6-[3-[4-(diphenylmethoxy)piperidino]-propoxy]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate

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Chemical Property of tert-Butyl 2-[6-[3-[4-(diphenylmethoxy)piperidino]-propoxy]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate

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Technology Process of tert-Butyl 2-[6-[3-[4-(diphenylmethoxy)piperidino]-propoxy]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate

There total 5 articles about tert-Butyl 2-[6-[3-[4-(diphenylmethoxy)piperidino]-propoxy]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 215530-66-8
tert-butyl 2-(6-chloroimidazo[1,2-b]pyridazin-2-yl)-2-methylpropionate

: 215530-54-4
4-(diphenylmethoxy)-1-piperidinepropanol

: 215529-48-9
tert-Butyl 2-[6-[3-[4-(diphenylmethoxy)piperidino]-propoxy]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate

Guidance literature:: 4-(diphenylmethoxy)-1-piperidinepropanol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

tert-butyl 2-(6-chloroimidazo[1,2-b]pyridazin-2-yl)-2-methylpropionate; In N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1248/cpb.51.122

Reference yield:

: 63891-88-3
ethyl 4-bromo-2,2-dimethyl-3-oxobutanoate

: 215529-48-9
tert-Butyl 2-[6-[3-[4-(diphenylmethoxy)piperidino]-propoxy]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 60 percent / Na₂HPO₄ / ethanol / 8 h / Heating

2.1: 34 percent / 1 N aq. NaOH / tetrahydrofuran / 24 h / 20 °C

3.1: 48 percent / toluene / 1 h / 80 °C

4.1: NaH / dimethylformamide / 0.5 h / 20 °C

4.2: 58 percent / dimethylformamide / 8 h / 20 °C

With sodium hydroxide; disodium hydrogenphosphate; sodium hydride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.51.122

Reference yield:

: 58258-01-8
4-diphenylmethoxypiperidine

: 215529-48-9
tert-Butyl 2-[6-[3-[4-(diphenylmethoxy)piperidino]-propoxy]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 78 percent / K₂CO₃ / dimethylformamide / 15 h / 20 °C

2.1: NaH / dimethylformamide / 0.5 h / 20 °C

2.2: 58 percent / dimethylformamide / 8 h / 20 °C

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.51.122