2-[6-[3-[4-(diphenylmethoxy)piperidino]-propoxy]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionic acid

Base Information

Chemical Name:2-[6-[3-[4-(diphenylmethoxy)piperidino]-propoxy]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionic acid
CAS No.:215529-50-3
Molecular Formula:C₃₁H₃₆N₄O₄
Molecular Weight:528.651
Hs Code.:

Synonyms:2-[6-[3-[4-(diphenylmethoxy)piperidino]-propoxy]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionic acid

Suppliers and Price of 2-[6-[3-[4-(diphenylmethoxy)piperidino]-propoxy]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[6-[3-[4-(diphenylmethoxy)piperidino]-propoxy]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-[6-[3-[4-(diphenylmethoxy)piperidino]-propoxy]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionic acid

There total 7 articles about 2-[6-[3-[4-(diphenylmethoxy)piperidino]-propoxy]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 215529-48-9
tert-Butyl 2-[6-[3-[4-(diphenylmethoxy)piperidino]-propoxy]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate

: 215529-50-3
2-[6-[3-[4-(diphenylmethoxy)piperidino]-propoxy]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionic acid

Guidance literature:: With potassium hydroxide; In butan-1-ol; at 90 ℃; for 14h;
DOI:10.1248/cpb.51.122

Reference yield:

: 63891-88-3
ethyl 4-bromo-2,2-dimethyl-3-oxobutanoate

: 215529-50-3
2-[6-[3-[4-(diphenylmethoxy)piperidino]-propoxy]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 60 percent / Na₂HPO₄ / ethanol / 8 h / Heating

2.1: 34 percent / 1 N aq. NaOH / tetrahydrofuran / 24 h / 20 °C

3.1: 48 percent / toluene / 1 h / 80 °C

4.1: NaH / dimethylformamide / 0.5 h / 20 °C

4.2: 58 percent / dimethylformamide / 8 h / 20 °C

5.1: 62 percent / KOH / butan-1-ol / 14 h / 90 °C

With potassium hydroxide; sodium hydroxide; disodium hydrogenphosphate; sodium hydride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; butan-1-ol;
DOI:10.1248/cpb.51.122

Reference yield:

: 58258-01-8
4-diphenylmethoxypiperidine

: 215529-50-3
2-[6-[3-[4-(diphenylmethoxy)piperidino]-propoxy]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 78 percent / K₂CO₃ / dimethylformamide / 15 h / 20 °C

2.1: NaH / dimethylformamide / 0.5 h / 20 °C

2.2: 58 percent / dimethylformamide / 8 h / 20 °C

3.1: 62 percent / KOH / butan-1-ol / 14 h / 90 °C

With potassium hydroxide; sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1248/cpb.51.122