(R)-2-<(1,1-dimethylethyl)dimethylsilyloxy>-2-(3-phenoxyphenyl)acetonitrile

Base Information

Chemical Name:(R)-2-<(1,1-dimethylethyl)dimethylsilyloxy>-2-(3-phenoxyphenyl)acetonitrile
CAS No.:160518-85-4
Molecular Formula:C₂₀H₂₅NO₂Si
Molecular Weight:339.51
Hs Code.:

Synonyms:(R)-2-<(1,1-dimethylethyl)dimethylsilyloxy>-2-(3-phenoxyphenyl)acetonitrile

Suppliers and Price of (R)-2-<(1,1-dimethylethyl)dimethylsilyloxy>-2-(3-phenoxyphenyl)acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-2-<(1,1-dimethylethyl)dimethylsilyloxy>-2-(3-phenoxyphenyl)acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-2-<(1,1-dimethylethyl)dimethylsilyloxy>-2-(3-phenoxyphenyl)acetonitrile

There total 1 articles about (R)-2-<(1,1-dimethylethyl)dimethylsilyloxy>-2-(3-phenoxyphenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 71962-66-8
(R)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile

: 18162-48-6
tert-butyldimethylsilyl chloride

: 160518-85-4
(R)-2-<(1,1-dimethylethyl)dimethylsilyloxy>-2-(3-phenoxyphenyl)acetonitrile

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(01)85686-6

Reference yield:

: 160518-85-4
(R)-2-<(1,1-dimethylethyl)dimethylsilyloxy>-2-(3-phenoxyphenyl)acetonitrile

: (R)-2-(tert-butylamino)-1-(3-phenoxyphenyl)ethan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 1M DIBAL; NH₄Br, 3.) NaBH₄ / 1.) toluene, ether, -70 deg C, 3 h; MeOH, -60 to -70 deg C, 10 min, 2.) toluene, MeOH, -70 deg C to room temp., 70 min, 3.) toluene, MeOH, 0 deg C to room temp., overnight

2: 77 percent / 40percent aq. HF / acetonitrile / 17 h / 50 °C

With sodium tetrahydroborate; hydrogen fluoride; diisobutylaluminium hydride; ammonium bromide; In acetonitrile;
DOI:10.1016/S0040-4020(01)85686-6

Reference yield:

: 75-64-9
tert-butylamine

: 160518-85-4
(R)-2-<(1,1-dimethylethyl)dimethylsilyloxy>-2-(3-phenoxyphenyl)acetonitrile

: 160518-86-5
(R)-α-<<(1,1-dimethylethyl)amino>methyl>-α-<(1,1-dimethylethyl)dimethylsilyloxy>-3-phenoxybenzenemethane

Guidance literature:: With sodium tetrahydroborate; diisobutylaluminium hydride; ammonium bromide; Yield given. Multistep reaction; 1.) toluene, ether, -70 deg C, 3 h; MeOH, -60 to -70 deg C, 10 min, 2.) toluene, MeOH, -70 deg C to room temp., 70 min, 3.) toluene, MeOH, 0 deg C to room temp., overnight;
DOI:10.1016/S0040-4020(01)85686-6