benzyl N-[1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate

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Chemical Name:benzyl N-[1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate
CAS No.:1235563-81-1
Molecular Formula:C₃₈H₄₉N₆O₁₀P
Molecular Weight:780.815
Hs Code.:

Synonyms:benzyl N-[1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate

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Chemical Property of benzyl N-[1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate

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Technology Process of benzyl N-[1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate

There total 6 articles about benzyl N-[1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

Diethyl phosphonate: 762-04-9,123-22-8
Diethyl phosphonate

: 1235563-92-4
benzyl (γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate trifluoroacetate

: 83-33-0
inden-1-one

: 1235563-81-1
benzyl N-[1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate

Guidance literature:: benzyl (γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate trifluoroacetate; inden-1-one; With [tetra(tert-butyl)phthalocyanine]aluminium chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 30 ℃; for 3h; Molecular sieve;

Diethyl phosphonate; In dichloromethane; at 30 ℃; for 96h; Molecular sievec;
DOI:10.1007/s11172-010-0063-x

Reference yield:

: 94770-45-3
benzyl Nα-Boc-Nω-nitro-L-argininate

: 1235563-81-1
benzyl N-[1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2 h

2.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 14 h / 4 °C

3.1: 2 h

4.1: [tetra(tert-butyl)phthalocyanine]aluminium chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 30 °C / Molecular sieve

4.2: 96 h / 30 °C / Molecular sievec

With [tetra(tert-butyl)phthalocyanine]aluminium chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; 4.1: Kabachnik-Fields reaction / 4.2: Kabachnik-Fields reaction;
DOI:10.1007/s11172-010-0063-x

Reference yield:

: 100-44-7
benzyl chloride

: 1235563-81-1
benzyl N-[1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 7 h / 80 °C

2.1: 2 h

3.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 14 h / 4 °C

4.1: 2 h

5.1: [tetra(tert-butyl)phthalocyanine]aluminium chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 30 °C / Molecular sieve

5.2: 96 h / 30 °C / Molecular sievec

With [tetra(tert-butyl)phthalocyanine]aluminium chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; 5.1: Kabachnik-Fields reaction / 5.2: Kabachnik-Fields reaction;
DOI:10.1007/s11172-010-0063-x