benzyl (γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate trifluoroacetate

Base Information

• Chemical Name: benzyl (γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate trifluoroacetate
• CAS No.: 1235563-92-4
• Molecular Formula: C₂HF₃O₂*C₂₅H₃₂N₆O₇
• Molecular Weight: 642.589
• Mol file: 1235563-92-4.mol

Synonyms:benzyl (γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate trifluoroacetate

Chemical Property of benzyl (γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate trifluoroacetate

There total 4 articles about benzyl (γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzyl Nα-Boc-(γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate (149836-44-2) + trifluoroacetic acid (76-05-1) → benzyl (γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate trifluoroacetate (1235563-92-4)

Guidance literature:

for 2h;

DOI:10.1007/s11172-010-0063-x

Reference yield:

Boc-Arg(NO2)-OH (2188-18-3) → benzyl (γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate trifluoroacetate (1235563-92-4)

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 7 h / 80 °C

2: 2 h

3: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 14 h / 4 °C

4: 2 h

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; sodium iodide; In N,N-dimethyl-formamide;

DOI:10.1007/s11172-010-0063-x

Reference yield:

benzyl Nα-Boc-Nω-nitro-L-argininate (94770-45-3) → benzyl (γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate trifluoroacetate (1235563-92-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 2 h

2: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 14 h / 4 °C

3: 2 h

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1007/s11172-010-0063-x

upstream raw materials:

benzyl Nα-Boc-Nω-nitro-L-argininate

benzyl Nα-Boc-(γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate

trifluoroacetic acid

Boc-Arg(NO₂)-OH

Downstream raw materials:

benzyl [Nα-(1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl)-Nω-nitro-L-arginyl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate

benzyl [Nα-(5-benzyloxycarbonyl-1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl)-Nω-nitro-L-arginyl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate

benzyl N-[1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate

benzyl Nα-Boc-Nω-nitro-L-arginyl-(γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate

Refernces