2-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)-1H-isoindole-1,3(2H)-dione

Base Information

Chemical Name:2-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)-1H-isoindole-1,3(2H)-dione
CAS No.:929693-86-7
Molecular Formula:C₂₀H₁₃F₃N₂O₂S
Molecular Weight:402.397
Hs Code.:

Synonyms:2-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)-1H-isoindole-1,3(2H)-dione

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Chemical Property of 2-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)-1H-isoindole-1,3(2H)-dione

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Technology Process of 2-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)-1H-isoindole-1,3(2H)-dione

There total 4 articles about 2-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 439134-78-8
5-(bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

: 1074-82-4
potassium phtalimide

: 929693-86-7
2-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)-1H-isoindole-1,3(2H)-dione

Guidance literature:: In N,N-dimethyl-formamide; at 70 ℃; for 18h;
DOI:10.1021/jm058056x

Reference yield:

: 175277-03-9
4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole-5-carboxylic acid ethyl ester

: 929693-86-7
2-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 80.2 g / LiAlH₄ / tetrahydrofuran / 1.3 h / 20 °C

2: 97 percent / PBr₃ / CH₂Cl₂ / 2 h / 20 °C

3: 91 percent / dimethylformamide / 18 h / 70 °C

With lithium aluminium tetrahydride; phosphorus tribromide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm058056x

Reference yield:

: 72505-21-6
4-trifluoromethylbenzthioamide

: 929693-86-7
2-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 24 h / Heating

2: 80.2 g / LiAlH₄ / tetrahydrofuran / 1.3 h / 20 °C

3: 97 percent / PBr₃ / CH₂Cl₂ / 2 h / 20 °C

4: 91 percent / dimethylformamide / 18 h / 70 °C

With lithium aluminium tetrahydride; phosphorus tribromide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm058056x