ethyl 2-methyl-2-[(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)amino]carbonyl}phenyl)oxy]propanoate

Base Information

Chemical Name:ethyl 2-methyl-2-[(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)amino]carbonyl}phenyl)oxy]propanoate
CAS No.:929693-87-8
Molecular Formula:C₂₅H₂₅F₃N₂O₄S
Molecular Weight:506.546
Hs Code.:

Synonyms:ethyl 2-methyl-2-[(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)amino]carbonyl}phenyl)oxy]propanoate

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Chemical Property of ethyl 2-methyl-2-[(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)amino]carbonyl}phenyl)oxy]propanoate

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Technology Process of ethyl 2-methyl-2-[(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)amino]carbonyl}phenyl)oxy]propanoate

There total 10 articles about ethyl 2-methyl-2-[(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)amino]carbonyl}phenyl)oxy]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 175277-03-9
4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole-5-carboxylic acid ethyl ester

: 929693-87-8
ethyl 2-methyl-2-[(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)amino]carbonyl}phenyl)oxy]propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 80.2 g / LiAlH₄ / tetrahydrofuran / 1.3 h / 20 °C

2: 97 percent / PBr₃ / CH₂Cl₂ / 2 h / 20 °C

3: 91 percent / dimethylformamide / 18 h / 70 °C

4: hydrazine hydrate / ethanol / 18 h / 90 °C

5: Et₃N / CH₂Cl₂ / 20 °C

With lithium aluminium tetrahydride; phosphorus tribromide; hydrazine hydrate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm058056x

Reference yield:

: 2-(4-chlorocarbonyl-phenoxy)-2-methyl-propionic acid ethyl ester

: 690632-25-8
({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)amine

: 929693-87-8
ethyl 2-methyl-2-[(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)amino]carbonyl}phenyl)oxy]propanoate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm058056x

Reference yield:

: 471907-20-7
4-{[2-(ethoxy)-1,1-dimethyl-2-oxoethyl]oxy}benzoic acid

: 929693-87-8
ethyl 2-methyl-2-[(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)amino]carbonyl}phenyl)oxy]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 3 h / Heating

2: Et₃N / CH₂Cl₂ / 20 °C

With thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1021/jm058056x