[4-(N,N-dimethylamino)phenyl]phenyl(4-trifluoromethylphenyl)methane

Base Information

• Chemical Name: [4-(N,N-dimethylamino)phenyl]phenyl(4-trifluoromethylphenyl)methane
• CAS No.: 1609277-75-9
• Molecular Formula: C₂₂H₂₀F₃N
• Molecular Weight: 355.403
• Mol file: 1609277-75-9.mol

Synonyms:[4-(N,N-dimethylamino)phenyl]phenyl(4-trifluoromethylphenyl)methane

Chemical Property of [4-(N,N-dimethylamino)phenyl]phenyl(4-trifluoromethylphenyl)methane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(N,N-dimethylamino)phenyl]phenyl(4-trifluoromethylphenyl)methane

There total 3 articles about [4-(N,N-dimethylamino)phenyl]phenyl(4-trifluoromethylphenyl)methane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

phenyl(4-trifluoromethylphenyl)methyl phenyl sulfone (1609277-65-7) + 4-(dimethylamino)benzene-boronic acid (28611-39-4) → [4-(N,N-dimethylamino)phenyl]phenyl(4-trifluoromethylphenyl)methane (1609277-75-9)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); sodium hydroxide; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; In 1,4-dioxane; water; at 120 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.201307019

Reference yield:

1-((phenylsulfonyl)methyl)-4-(trifluoromethyl)benzene (30932-38-8) → [4-(N,N-dimethylamino)phenyl]phenyl(4-trifluoromethylphenyl)methane (1609277-75-9)

Guidance literature:

Multi-step reaction with 2 steps

1: bis(η3-allyl-μ-chloropalladium(II)); tri tert-butylphosphoniumtetrafluoroborate; potassium tert-butylate / 1,4-dioxane / 12 h / 60 °C / Inert atmosphere

2: 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; sodium hydroxide; bis(η3-allyl-μ-chloropalladium(II)) / 1,4-dioxane; water / 12 h / 120 °C / Inert atmosphere

With bis(η3-allyl-μ-chloropalladium(II)); potassium tert-butylate; sodium hydroxide; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; water;

DOI:10.1002/anie.201307019

Reference yield:

p-trifluoromethylphenyl bromide (402-43-7) → [4-(N,N-dimethylamino)phenyl]phenyl(4-trifluoromethylphenyl)methane (1609277-75-9)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium diacetate; XPhos; lithium tert-butoxide / 12 h / 120 °C / Inert atmosphere

2: bis(η3-allyl-μ-chloropalladium(II)); tri tert-butylphosphoniumtetrafluoroborate; potassium tert-butylate / 1,4-dioxane / 12 h / 60 °C / Inert atmosphere

3: 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; sodium hydroxide; bis(η3-allyl-μ-chloropalladium(II)) / 1,4-dioxane; water / 12 h / 120 °C / Inert atmosphere

With bis(η3-allyl-μ-chloropalladium(II)); potassium tert-butylate; palladium diacetate; sodium hydroxide; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; lithium tert-butoxide; tri tert-butylphosphoniumtetrafluoroborate; XPhos; In 1,4-dioxane; water;

DOI:10.1002/anie.201307019

upstream raw materials:

phenyl(4-trifluoromethylphenyl)methyl phenyl sulfone

4-(dimethylamino)benzene-boronic acid

1-((phenylsulfonyl)methyl)-4-(trifluoromethyl)benzene

p-trifluoromethylphenyl bromide