phenyl(4-trifluoromethylphenyl)methyl phenyl sulfone

Base Information

• Chemical Name: phenyl(4-trifluoromethylphenyl)methyl phenyl sulfone
• CAS No.: 1609277-65-7
• Molecular Formula: C₂₀H₁₅F₃O₂S
• Molecular Weight: 376.399
• Mol file: 1609277-65-7.mol

Synonyms:phenyl(4-trifluoromethylphenyl)methyl phenyl sulfone

Chemical Property of phenyl(4-trifluoromethylphenyl)methyl phenyl sulfone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl(4-trifluoromethylphenyl)methyl phenyl sulfone

There total 3 articles about phenyl(4-trifluoromethylphenyl)methyl phenyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

iodobenzene (591-50-4) + 1-((phenylsulfonyl)methyl)-4-(trifluoromethyl)benzene (30932-38-8) → phenyl(4-trifluoromethylphenyl)methyl phenyl sulfone (1609277-65-7)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); potassium tert-butylate; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; at 60 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.201307019

Reference yield:

p-trifluoromethylphenyl bromide (402-43-7) → phenyl(4-trifluoromethylphenyl)methyl phenyl sulfone (1609277-65-7)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; XPhos; lithium tert-butoxide / 12 h / 120 °C / Inert atmosphere

2: bis(η3-allyl-μ-chloropalladium(II)); tri tert-butylphosphoniumtetrafluoroborate; potassium tert-butylate / 1,4-dioxane / 12 h / 60 °C / Inert atmosphere

With bis(η3-allyl-μ-chloropalladium(II)); potassium tert-butylate; palladium diacetate; lithium tert-butoxide; tri tert-butylphosphoniumtetrafluoroborate; XPhos; In 1,4-dioxane;

DOI:10.1002/anie.201307019

Reference yield:

methylphenylsulfonate (3112-85-4) → phenyl(4-trifluoromethylphenyl)methyl phenyl sulfone (1609277-65-7)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; XPhos; lithium tert-butoxide / 12 h / 120 °C / Inert atmosphere

2: bis(η3-allyl-μ-chloropalladium(II)); tri tert-butylphosphoniumtetrafluoroborate; potassium tert-butylate / 1,4-dioxane / 12 h / 60 °C / Inert atmosphere

With bis(η3-allyl-μ-chloropalladium(II)); potassium tert-butylate; palladium diacetate; lithium tert-butoxide; tri tert-butylphosphoniumtetrafluoroborate; XPhos; In 1,4-dioxane;

DOI:10.1002/anie.201307019

upstream raw materials:

iodobenzene

1-((phenylsulfonyl)methyl)-4-(trifluoromethyl)benzene

p-trifluoromethylphenyl bromide

methylphenylsulfonate

Downstream raw materials:

[4-(N,N-dimethylamino)phenyl]phenyl(4-trifluoromethylphenyl)methane