1-P-TOLYL-PIPERIDIN-2-ONE

Base Information

• Chemical Name: 1-P-TOLYL-PIPERIDIN-2-ONE
• CAS No.: 4789-11-1
• Molecular Formula: C12H15 N O
• Molecular Weight: 189.257
• Mol file: 4789-11-1.mol

Synonyms:2-Piperidone,1-p-tolyl- (7CI,8CI); 1-p-Tolyl-2-piperidinone

Chemical Property of 1-P-TOLYL-PIPERIDIN-2-ONE

Chemical Property:

• Melting Point: 87 °C
• Boiling Point: 397.1±21.0 °C(Predicted)
• PKA: 1.06±0.20(Predicted)
• PSA: 20.31000
• Density: 1.084±0.06 g/cm3(Predicted)
• LogP: 2.57690

Purity/Quality:

99%, ^*data from raw suppliers

1-(PARA-TOLYL)-PIPERIDIN-2-ONE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-P-TOLYL-PIPERIDIN-2-ONE

There total 7 articles about 1-P-TOLYL-PIPERIDIN-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5-chlorovaleric acid p-toluidide (110224-25-4) → N-(4-methylphenyl)-δ-valerolactam (4789-11-1)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.3987/COM-97-8061

Reference yield: 63.0%

1 ,5-pentanediol (111-29-5) + p-toluidine (106-49-0,12221-03-3) → N-(4-methylphenyl)-δ-valerolactam (4789-11-1)

Guidance literature:

With dodecacarbonyl-triangulo-triruthenium; C₃₂H₃₄N₃P₂⁽¹⁺⁾*Cl^(1-); caesium carbonate; at 140 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c9cc06339k

Reference yield: 56.0%

N-(4-methylphenyl)piperidine (31053-03-9) → N-(4-methylphenyl)-δ-valerolactam (4789-11-1)

Guidance literature:

With water; iodine; sodium hydrogencarbonate; In tetrahydrofuran; at 20 ℃; for 4h; chemoselective reaction;

DOI:10.1021/acs.orglett.7b00021

upstream raw materials:

p-methylazidobenzene

carbon monoxide

5-chlorovaleric acid p-toluidide

N-(4-methylphenyl)piperidine

Refernces

• 1、 Zheng, Yanling,Nie, Xufeng,Long, Yang,Ji, Li,Fu, Haiyan,Zheng, Xueli,Chen, Hua,Li, Ruixiang. "Ruthenium-catalyzed synthesis of: N -substituted lactams by acceptorless dehydrogenative coupling of diols with primary amines". supporting information. p. 12384 - 12387. Retrieved 2019/10/19.
• 2、 Griffiths, Robert J.,Burley, Glenn A.,Talbot, Eric P. A.. "Transition-Metal-Free Amine Oxidation: A Chemoselective Strategy for the Late-Stage Formation of Lactams". supporting information. p. 870 - 873. Retrieved 2017/02/26.