methyl (1S,2R,3S,4R)-3-[(4-fluorobenzyl)amino]bicyclo[2.2.1]heptane-2-carboxylate

Base Information

Chemical Name:methyl (1S,2R,3S,4R)-3-[(4-fluorobenzyl)amino]bicyclo[2.2.1]heptane-2-carboxylate
CAS No.:1071520-21-2
Molecular Formula:C₁₆H₂₀FNO₂
Molecular Weight:277.339
Hs Code.:

Synonyms:methyl (1S,2R,3S,4R)-3-[(4-fluorobenzyl)amino]bicyclo[2.2.1]heptane-2-carboxylate

Suppliers and Price of methyl (1S,2R,3S,4R)-3-[(4-fluorobenzyl)amino]bicyclo[2.2.1]heptane-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of methyl (1S,2R,3S,4R)-3-[(4-fluorobenzyl)amino]bicyclo[2.2.1]heptane-2-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of methyl (1S,2R,3S,4R)-3-[(4-fluorobenzyl)amino]bicyclo[2.2.1]heptane-2-carboxylate

There total 7 articles about methyl (1S,2R,3S,4R)-3-[(4-fluorobenzyl)amino]bicyclo[2.2.1]heptane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Methyl (1S,2R,3S,4R)-3-[(4-Fluorobenzyl)amino]bicyclo[2.2.1]heptane-2-carboxylate Methyl (1S,2R,3S,4R)-3-aminobicyclo[2.2.1]heptane-2-carboxylate hydrochloride: Methyl (1S,2R,3S,4R)-3-[(4-Fluorobenzyl)amino]bicyclo[2.2.1]heptane-2-carboxylate Methyl (1S,2R,3S,4R)-3-aminobicyclo[2.2.1]heptane-2-carboxylate hydrochloride

: 459-57-4
4-fluorobenzaldehyde

: 1071520-21-2
methyl (1S,2R,3S,4R)-3-[(4-fluorobenzyl)amino]bicyclo[2.2.1]heptane-2-carboxylate

Guidance literature:: With sodium acetate; sodium cyanoborohydride; silica gel; In methanol; sodium hydrogencarbonate; ethyl acetate;

Reference yield: 98.0%

: 1071520-19-8
methyl (1S,2R,3S,4R)-3-amino-bicyclo[2.2.1]heptane-2-carboxylate hydrochloride

: 459-57-4
4-fluorobenzaldehyde

: 1071520-21-2
methyl (1S,2R,3S,4R)-3-[(4-fluorobenzyl)amino]bicyclo[2.2.1]heptane-2-carboxylate

Guidance literature:: methyl (1S,2R,3S,4R)-3-amino-bicyclo[2.2.1]heptane-2-carboxylate hydrochloride; 4-fluorobenzaldehyde; With sodium acetate; sodium cyanoborohydride; In methanol; at 25 ℃; for 16h; Molecular sieve;

With sodium hydrogencarbonate; In methanol; water; ethyl acetate;

Reference yield:

: 1071520-16-5
(1R,2R,3S,4S)-3-benzyloxycarbonylamino-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester

: 1071520-21-2
methyl (1S,2R,3S,4R)-3-[(4-fluorobenzyl)amino]bicyclo[2.2.1]heptane-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 16 h / 25 °C

2: sodium acetate; sodium cyanoborohydride / methanol / 16 h / 25 °C / Molecular sieve

With hydrogen; sodium acetate; sodium cyanoborohydride; 5%-palladium/activated carbon; In methanol; ethyl acetate;