(2S,2′S)-dimethyl 3,3′-(5,5′-dibromo-6,6′-dihydroxybiphenyl-3,3′-diyl)bis(2-(benzyloxycarbonylamino)propanoate)

Base Information

Chemical Name:(2S,2′S)-dimethyl 3,3′-(5,5′-dibromo-6,6′-dihydroxybiphenyl-3,3′-diyl)bis(2-(benzyloxycarbonylamino)propanoate)
CAS No.:1394296-00-4
Molecular Formula:C₃₆H₃₄Br₂N₂O₁₀
Molecular Weight:814.481
Hs Code.:

Synonyms:(2S,2′S)-dimethyl 3,3′-(5,5′-dibromo-6,6′-dihydroxybiphenyl-3,3′-diyl)bis(2-(benzyloxycarbonylamino)propanoate)

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Chemical Property of (2S,2′S)-dimethyl 3,3′-(5,5′-dibromo-6,6′-dihydroxybiphenyl-3,3′-diyl)bis(2-(benzyloxycarbonylamino)propanoate)

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Technology Process of (2S,2′S)-dimethyl 3,3′-(5,5′-dibromo-6,6′-dihydroxybiphenyl-3,3′-diyl)bis(2-(benzyloxycarbonylamino)propanoate)

There total 2 articles about (2S,2′S)-dimethyl 3,3′-(5,5′-dibromo-6,6′-dihydroxybiphenyl-3,3′-diyl)bis(2-(benzyloxycarbonylamino)propanoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 132149-66-7
dimethyl 3,3′-(6,6′-dihydroxybiphenyl-3,3′-diyl)bis[2-(benzyloxycarbonylamino)propanoate]

: 1394296-00-4
(2S,2′S)-dimethyl 3,3′-(5,5′-dibromo-6,6′-dihydroxybiphenyl-3,3′-diyl)bis(2-(benzyloxycarbonylamino)propanoate)

Guidance literature:: With N-Bromosuccinimide; In acetonitrile; at 0 ℃; for 0.25h; Inert atmosphere;
DOI:10.1039/c2ob25874a

Reference yield:

: 13512-31-7
N-(benzyloxycarbonyl)-L-tyrosine methyl ester

: 1394296-00-4
(2S,2′S)-dimethyl 3,3′-(5,5′-dibromo-6,6′-dihydroxybiphenyl-3,3′-diyl)bis(2-(benzyloxycarbonylamino)propanoate)

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid; thallium(III) trifluoroacetate; vanadium(V) oxytrifluoride / dichloromethane; ethyl acetate / 0.75 h / -20 °C / Inert atmosphere

2: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere

With N-Bromosuccinimide; vanadium(V) oxytrifluoride; trifluoroacetic acid; thallium(III) trifluoroacetate; In dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1039/c2ob25874a

Reference yield: 26.0%

: 75-11-6
diiodomethane

: 1394296-00-4
(2S,2′S)-dimethyl 3,3′-(5,5′-dibromo-6,6′-dihydroxybiphenyl-3,3′-diyl)bis(2-(benzyloxycarbonylamino)propanoate)

: 1394296-02-6
(2S,2′S)-dimethyl 3,3′-(4,8-dibromodibenzo[d,f ][1,3]dioxepine-2,10-diyl)bis(2-(benzyloxycarbonylamino)propanoate)

Guidance literature:: (2S,2′S)-dimethyl 3,3′-(5,5′-dibromo-6,6′-dihydroxybiphenyl-3,3′-diyl)bis(2-(benzyloxycarbonylamino)propanoate); With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

diiodomethane; at 50 ℃; for 29h;
DOI:10.1039/c2ob25874a