(2S,2′S)-3,3′-(4,8-dibromodibenzo[d,f][1,3]dioxepine-2,10-diyl)-bis(2-(benzyloxycarbonylamino)propanoic acid)

Base Information

Chemical Name:(2S,2′S)-3,3′-(4,8-dibromodibenzo[d,f][1,3]dioxepine-2,10-diyl)-bis(2-(benzyloxycarbonylamino)propanoic acid)
CAS No.:1394296-04-8
Molecular Formula:C₃₅H₃₀Br₂N₂O₁₀
Molecular Weight:798.439
Hs Code.:

Synonyms:(2S,2′S)-3,3′-(4,8-dibromodibenzo[d,f][1,3]dioxepine-2,10-diyl)-bis(2-(benzyloxycarbonylamino)propanoic acid)

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Chemical Property of (2S,2′S)-3,3′-(4,8-dibromodibenzo[d,f][1,3]dioxepine-2,10-diyl)-bis(2-(benzyloxycarbonylamino)propanoic acid)

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Technology Process of (2S,2′S)-3,3′-(4,8-dibromodibenzo[d,f][1,3]dioxepine-2,10-diyl)-bis(2-(benzyloxycarbonylamino)propanoic acid)

There total 4 articles about (2S,2′S)-3,3′-(4,8-dibromodibenzo[d,f][1,3]dioxepine-2,10-diyl)-bis(2-(benzyloxycarbonylamino)propanoic acid) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1394296-02-6
(2S,2′S)-dimethyl 3,3′-(4,8-dibromodibenzo[d,f ][1,3]dioxepine-2,10-diyl)bis(2-(benzyloxycarbonylamino)propanoate)

: 1394296-04-8
(2S,2′S)-3,3′-(4,8-dibromodibenzo[d,f][1,3]dioxepine-2,10-diyl)-bis(2-(benzyloxycarbonylamino)propanoic acid)

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1039/c2ob25874a

Reference yield:

: 1394296-00-4
(2S,2′S)-dimethyl 3,3′-(5,5′-dibromo-6,6′-dihydroxybiphenyl-3,3′-diyl)bis(2-(benzyloxycarbonylamino)propanoate)

: 1394296-04-8
(2S,2′S)-3,3′-(4,8-dibromodibenzo[d,f][1,3]dioxepine-2,10-diyl)-bis(2-(benzyloxycarbonylamino)propanoic acid)

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

1.2: 29 h / 50 °C

2.1: lithium hydroxide / tetrahydrofuran; water / 5 h / 20 °C / Inert atmosphere

With sodium hydride; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1039/c2ob25874a

Reference yield:

: 132149-66-7
dimethyl 3,3′-(6,6′-dihydroxybiphenyl-3,3′-diyl)bis[2-(benzyloxycarbonylamino)propanoate]

: 1394296-04-8
(2S,2′S)-3,3′-(4,8-dibromodibenzo[d,f][1,3]dioxepine-2,10-diyl)-bis(2-(benzyloxycarbonylamino)propanoic acid)

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

2.2: 29 h / 50 °C

3.1: lithium hydroxide / tetrahydrofuran; water / 5 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; sodium hydride; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c2ob25874a