(3S,9aS)-tert-butyl 3-(3-cyano-4-fluoro-2-methylphenyl)hexahydro-1H-pyrazino[1,2-a ]pyrazine-2(6H)-carboxylate

Base Information

Chemical Name:(3S,9aS)-tert-butyl 3-(3-cyano-4-fluoro-2-methylphenyl)hexahydro-1H-pyrazino[1,2-a ]pyrazine-2(6H)-carboxylate
CAS No.:1426071-32-0
Molecular Formula:C₂₀H₂₇FN₄O₂
Molecular Weight:374.458
Hs Code.:

Synonyms:(3S,9aS)-tert-butyl 3-(3-cyano-4-fluoro-2-methylphenyl)hexahydro-1H-pyrazino[1,2-a ]pyrazine-2(6H)-carboxylate

Suppliers and Price of (3S,9aS)-tert-butyl 3-(3-cyano-4-fluoro-2-methylphenyl)hexahydro-1H-pyrazino[1,2-a ]pyrazine-2(6H)-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,9aS)-tert-butyl 3-(3-cyano-4-fluoro-2-methylphenyl)hexahydro-1H-pyrazino[1,2-a ]pyrazine-2(6H)-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,9aS)-tert-butyl 3-(3-cyano-4-fluoro-2-methylphenyl)hexahydro-1H-pyrazino[1,2-a ]pyrazine-2(6H)-carboxylate

There total 9 articles about (3S,9aS)-tert-butyl 3-(3-cyano-4-fluoro-2-methylphenyl)hexahydro-1H-pyrazino[1,2-a ]pyrazine-2(6H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426071-31-9
(3S,9aS)-8-benzyl 2-tert-butyl 3-(3-cyano-4-fluoro-2-methylphenyl)tetrahydro-1H-pyrazino[1,2-a]pyrazine-2,8 (9H,9aH)-dicarboxylate

: 1426071-32-0
(3S,9aS)-tert-butyl 3-(3-cyano-4-fluoro-2-methylphenyl)hexahydro-1H-pyrazino[1,2-a ]pyrazine-2(6H)-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

Reference yield:

: 883502-14-5
1-fluoro-2-iodo-3-methylbenzene

: 1426071-32-0
(3S,9aS)-tert-butyl 3-(3-cyano-4-fluoro-2-methylphenyl)hexahydro-1H-pyrazino[1,2-a ]pyrazine-2(6H)-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl acetamide / 16 h / 80 °C / Inert atmosphere

2.1: trifluorormethanesulfonic acid; N-Bromosuccinimide / 1 h / 0 - 20 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / ethanol / 4 h / Inert atmosphere; Reflux

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 72 h / 0 - 20 °C

5.1: ethanol / 0.5 h / 150 °C / Microwave irradiation

6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

6.2: 1 h / 0 °C

7.1: thionyl chloride / 1 h / 90 °C

7.2: 1 h / 0 - 90 °C / Sealed tube

8.1: 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 4 h / 35 °C

8.2: 20 °C

9.1: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,3-dimethylbarbituric acid; trifluorormethanesulfonic acid; palladium 10% on activated carbon; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In methanol; ethanol; dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 1255207-47-6
3-bromo-6-fluoro-2-methyl-benzonitrile

: 1426071-32-0
(3S,9aS)-tert-butyl 3-(3-cyano-4-fluoro-2-methylphenyl)hexahydro-1H-pyrazino[1,2-a ]pyrazine-2(6H)-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / ethanol / 4 h / Inert atmosphere; Reflux

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 72 h / 0 - 20 °C

3.1: ethanol / 0.5 h / 150 °C / Microwave irradiation

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.2: 1 h / 0 °C

5.1: thionyl chloride / 1 h / 90 °C

5.2: 1 h / 0 - 90 °C / Sealed tube

6.1: 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 4 h / 35 °C

6.2: 20 °C

7.1: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,3-dimethylbarbituric acid; palladium 10% on activated carbon; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In methanol; ethanol; dichloromethane;