benzyl 5-(4-fluorophenyl)-7,8-dihydro-7-methyl-8-oxo-6-pyrido<3,4-b>pyridinecarboxylate

Base Information

Chemical Name:benzyl 5-(4-fluorophenyl)-7,8-dihydro-7-methyl-8-oxo-6-pyrido<3,4-b>pyridinecarboxylate
CAS No.:168541-95-5
Molecular Formula:C₂₃H₁₇FN₂O₃
Molecular Weight:388.398
Hs Code.:

Synonyms:benzyl 5-(4-fluorophenyl)-7,8-dihydro-7-methyl-8-oxo-6-pyrido<3,4-b>pyridinecarboxylate

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Chemical Property of benzyl 5-(4-fluorophenyl)-7,8-dihydro-7-methyl-8-oxo-6-pyrido<3,4-b>pyridinecarboxylate

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Technology Process of benzyl 5-(4-fluorophenyl)-7,8-dihydro-7-methyl-8-oxo-6-pyrido<3,4-b>pyridinecarboxylate

There total 6 articles about benzyl 5-(4-fluorophenyl)-7,8-dihydro-7-methyl-8-oxo-6-pyrido<3,4-b>pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 168541-94-4
N-<(benzyloxycarbonyl)methyl>-3-(4-fluorobenzoyl)-N-methyl-2-pyridinecarboxamide

: 168541-95-5
benzyl 5-(4-fluorophenyl)-7,8-dihydro-7-methyl-8-oxo-6-pyrido<3,4-b>pyridinecarboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; for 12h; Heating;
DOI:10.1021/jm00016a014

Reference yield:

: 462-06-6
fluorobenzene

: 168541-95-5
benzyl 5-(4-fluorophenyl)-7,8-dihydro-7-methyl-8-oxo-6-pyrido<3,4-b>pyridinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: AlCl₃ / 4 h / Heating

2: SOCl₂, DMF / tetrahydrofuran / 1 h / Heating

3: Et₃N / tetrahydrofuran / Ambient temperature

4: 22 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / toluene / 12 h / Heating

With aluminium trichloride; thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; toluene;
DOI:10.1021/jm00016a014

Reference yield:

: 699-98-9
Pyridine-2,3-dicarboxylic anhydride

: 168541-95-5
benzyl 5-(4-fluorophenyl)-7,8-dihydro-7-methyl-8-oxo-6-pyrido<3,4-b>pyridinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: AlCl₃ / 4 h / Heating

2: SOCl₂, DMF / tetrahydrofuran / 1 h / Heating

3: Et₃N / tetrahydrofuran / Ambient temperature

4: 22 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / toluene / 12 h / Heating

With aluminium trichloride; thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; toluene;
DOI:10.1021/jm00016a014