^tBOC-(S)-Ala-ΔPhe-(S)-Leu-NH2

Base Information

Chemical Name:^tBOC-(S)-Ala-ΔPhe-(S)-Leu-NH2
CAS No.:93199-89-4
Molecular Formula:C₂₃H₃₄N₄O₅
Molecular Weight:446.547
Hs Code.:

<sup>t</sup>BOC-(S)-Ala-ΔPhe-(S)-Leu-NH2

Synonyms:^tBOC-(S)-Ala-ΔPhe-(S)-Leu-NH2

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Chemical Property of ^tBOC-(S)-Ala-ΔPhe-(S)-Leu-NH2

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Technology Process of ^tBOC-(S)-Ala-ΔPhe-(S)-Leu-NH2

There total 8 articles about ^tBOC-(S)-Ala-ΔPhe-(S)-Leu-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15761-38-3
L-N-Boc-Ala

: 93199-89-4
^tBOC-(S)-Ala-ΔPhe-(S)-Leu-NH2

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / 1-hydroxybenzotriazole, N-methylmorpholine, N,N-dicyclohexylcarbodiimide / dimethylformamide / 2 h, 0 deg C then 12 h, 25 deg C

2: 96 percent / 1N NaOH / H₂O; methanol / 2 h / 0 °C

3: 89 percent / NaOAc, Ac₂O / 1 h, 0 deg C then 12 h, 25 deg C

4: 81 percent / Et₃N / CHCl₃ / 1 h, 0 deg C then 40 h, 25 deg C

5: 2N NaOH / H₂O; methanol / 5 °C

6: N-methylmorpholine / tetrahydrofuran / -15 °C

7: ammonia

With 4-methyl-morpholine; sodium hydroxide; ammonia; sodium acetate; acetic anhydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)82412-1

Reference yield:

: 42267-16-3
(d,l)-phenylserine ethyl ester hydrochloride

: 93199-89-4
^tBOC-(S)-Ala-ΔPhe-(S)-Leu-NH2

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / 1-hydroxybenzotriazole, N-methylmorpholine, N,N-dicyclohexylcarbodiimide / dimethylformamide / 2 h, 0 deg C then 12 h, 25 deg C

2: 96 percent / 1N NaOH / H₂O; methanol / 2 h / 0 °C

3: 89 percent / NaOAc, Ac₂O / 1 h, 0 deg C then 12 h, 25 deg C

4: 81 percent / Et₃N / CHCl₃ / 1 h, 0 deg C then 40 h, 25 deg C

5: 2N NaOH / H₂O; methanol / 5 °C

6: N-methylmorpholine / tetrahydrofuran / -15 °C

7: ammonia

With 4-methyl-morpholine; sodium hydroxide; ammonia; sodium acetate; acetic anhydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)82412-1

Reference yield:

: 116908-50-0
Boc-Ala-Δ^ZPhe azlactone

: 93199-89-4
^tBOC-(S)-Ala-ΔPhe-(S)-Leu-NH2

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / Et₃N / CHCl₃ / 1 h, 0 deg C then 40 h, 25 deg C

2: 2N NaOH / H₂O; methanol / 5 °C

3: N-methylmorpholine / tetrahydrofuran / -15 °C

4: ammonia

With 4-methyl-morpholine; sodium hydroxide; ammonia; triethylamine; In tetrahydrofuran; methanol; chloroform; water;
DOI:10.1016/S0040-4020(01)82412-1