42267-16-3

Basic information

• Product Name: 2-AMINO-3-HYDROXY-3-PHENYL-PROPIONIC ACID ETHYL ESTER HYDROCHLORIDE
• Synonyms: 2-AMINO-3-HYDROXY-3-PHENYL-PROPIONIC ACID ETHYL ESTER HYDROCHLORIDE;ethyl 2-amino-3-hydroxy-3-phenylpropanoate hydrochloride
• CAS NO: 42267-16-3
• Molecular Formula: C₁₁H₁₅NO₃*ClH
• Molecular Weight: 245.7
• Mol File: 42267-16-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 137.5-139 °C(Solv: ethanol (64-17-5))
• Boiling Point: 357.7°C at 760 mmHg
• Flash Point: 170.1°C
• Appearance: /
• Density: 1.178g/cm³
• Vapor Pressure: 9.76E-06mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: 2-AMINO-3-HYDROXY-3-PHENYL-PROPIONIC ACID ETHYL ESTER HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3-HYDROXY-3-PHENYL-PROPIONIC ACID ETHYL ESTER HYDROCHLORIDE(42267-16-3)
• EPA Substance Registry System: 2-AMINO-3-HYDROXY-3-PHENYL-PROPIONIC ACID ETHYL ESTER HYDROCHLORIDE(42267-16-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 42267-16-3(Hazardous Substances Data)

Usage

General Description

2-AMINO-3-HYDROXY-3-PHENYL-PROPIONIC ACID ETHYL ESTER HYDROCHLORIDE is a chemical compound that is a hydrochloride salt of 2-amino-3-hydroxy-3-phenyl-propionic acid ethyl ester. It is commonly used in the pharmaceutical industry as a precursor for the synthesis of various pharmaceutical drugs. 2-AMINO-3-HYDROXY-3-PHENYL-PROPIONIC ACID ETHYL ESTER HYDROCHLORIDE has potential biological activities and is believed to have analgesic and anti-inflammatory properties. It is also used as a building block for the synthesis of various amino acid derivatives and is considered to be an important intermediate in organic synthesis. Additionally, this compound may have potential applications in the treatment of certain medical conditions, and further research is being conducted to explore its therapeutic uses.

InChI:InChI=1/C11H15NO3/c1-2-15-11(14)9(12)10(13)8-6-4-3-5-7-8/h3-7,9-10,13H,2,12H2,1H3

Upstream product

• 64-17-5 ethanol 
• 69-96-5 dl-threo-phenylserine 
• 623-33-6 glycine ethyl ester hydrochloride 
• 100-52-7 benzaldehyde 

Downstream Products

• 93199-93-0 2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-3-hydroxy-3-phenyl-propionic acid ethyl ester 
• 64951-85-5 (+/-)-(2,5c-diphenyl-4,5-dihydro-oxazol-4r-yl)-methanol 
• 53732-41-5 ((4R)-2-methyl-5t-phenyl-4,5-dihydro-oxazol-4r-yl)-methanol 
• 582295-24-7 (2S,3R)-2-amino-3-hydroxy-3-(4-nitro-phenyl)-propionic acid ethyl ester 
• 13789-58-7 (+/-)-cis-4-amino-5-phenyl-isoxazolidin-3-one 
• 906366-62-9 (2S,3S)-2-(2,2-dichloro-acetylamino)-3-hydroxy-3-phenyl-propionic acid 
• 92963-95-6 (2RS,3RS)-2-benzoylamino-3-hydroxy-3-phenyl-propionic acid 
• 906366-38-9 (2R,3R)-2-benzoylamino-3-hydroxy-3-phenyl-propionic acid 
• 92963-95-6 (2S,3S)-2-benzoylamino-3-hydroxy-3-phenyl-propionic acid 
• 32946-42-2 (2S,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid 
• 115861-43-3 (2S,3R)-3-hydroxy-2-[N^ω-nitro-α-(4-nitro-benzyloxycarbonyl)-L-arginylamino]-3-phenyl-propionic acid 
• 92963-95-6 (2RS,3SR)-2-benzoylamino-3-hydroxy-3-phenylpropanoic acid 
• 50610-93-0 (1RS,2RS)-2-benzoylamino-1-phenyl-propane-1,3-diol 
• 46506-67-6 (2RS,3SR)-2-acetylamino-3-hydroxy-3-phenyl-propionic acid 

Relevant articles and documents

Synthesis of α-hydroxy-β-triflamido carboxylic esters through ring-opening of alkoxycarbonyl oxiranes

The oxirane ring of 3-alkyl- and 3-arylglycidic esters has been opened with trifluoromethanesulfonamide (TfNH2) under solid-liquid heterogeneous conditions. The corresponding α-hydroxy-β-triflamido sters were produced in good yields, in a regio- and stereoselective fashion. Several reaction parameters, such as the nature of the base, the presence of a phase transfer catalyst and/or a solvent have been examined. Georg Thieme Verlag Stuttgart.