1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one

Base Information

• Chemical Name: 1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one
• CAS No.: 1255792-04-1
• Molecular Formula: C₁₂H₁₁NO₅
• Molecular Weight: 249.223
• Mol file: 1255792-04-1.mol

Synonyms:1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one

Chemical Property of 1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one

There total 5 articles about 1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

propargyl bromide (106-96-7) + 1-(4-hydroxy-5-methoxy-2-nitrophenyl)ethan-1-one (418759-58-7) → 1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one (1255792-04-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃;

DOI:10.1021/ja108258d

Reference yield: 84.0%

1-(3-methoxy-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one (956597-80-1) → 1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one (1255792-04-1)

Guidance literature:

With nitric acid; acetic anhydride; at 0 - 20 ℃; for 0.75h;

DOI:10.1002/chem.201404919

Reference yield:

1-(3-methoxy-4-hydroxyphenyl)ethanone (498-02-2) → 1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one (1255792-04-1)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: nitric acid; acetic acid

3: trifluoroacetic acid

4: potassium carbonate / N,N-dimethyl-formamide / 50 °C

With nitric acid; potassium carbonate; acetic acid; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/ja108258d

upstream raw materials:

4-benzyloxy-3-methoxyacetophenone

propargyl bromide

1-(4-hydroxy-5-methoxy-2-nitrophenyl)ethan-1-one

1-(3-methoxy-4-hydroxyphenyl)ethanone

Downstream raw materials:

2-(5-methoxy-2-nitro-4-propargyloxy-α-methylbenzyloxy)ethanol

C₆₅H₉₄N₂O₁₈

2-methyl-2-(5-methoxy-2-nitro-4-propargyloxyphenyl)-1,3-dioxolane

1-(1-(5-methoxy-2-nitro-4-((1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethyl)-3-(octylthio)pyrrolidine-2,5-dione