2-(5-methoxy-2-nitro-4-propargyloxy-α-methylbenzyloxy)ethanol

Base Information

• Chemical Name: 2-(5-methoxy-2-nitro-4-propargyloxy-α-methylbenzyloxy)ethanol
• CAS No.: 1260586-86-4
• Molecular Formula: C₁₄H₁₇NO₆
• Molecular Weight: 295.292
• Mol file: 1260586-86-4.mol

Synonyms:

Chemical Property of 2-(5-methoxy-2-nitro-4-propargyloxy-α-methylbenzyloxy)ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(5-methoxy-2-nitro-4-propargyloxy-α-methylbenzyloxy)ethanol

There total 6 articles about 2-(5-methoxy-2-nitro-4-propargyloxy-α-methylbenzyloxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-methyl-2-(5-methoxy-2-nitro-4-propargyloxyphenyl)-1,3-dioxolane (1260586-85-3) → 2-(5-methoxy-2-nitro-4-propargyloxy-α-methylbenzyloxy)ethanol (1260586-86-4)

Guidance literature:

With titanium tetrachloride; sodium cyanoborohydride; In acetonitrile; Cooling with ice; Inert atmosphere;

DOI:10.1021/ja108258d

Reference yield:

1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one (1255792-04-1) → 2-(5-methoxy-2-nitro-4-propargyloxy-α-methylbenzyloxy)ethanol (1260586-86-4)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 18 h / Reflux

2: titanium tetrachloride; sodium cyanoborohydride / acetonitrile / Cooling with ice; Inert atmosphere

With titanium tetrachloride; sodium cyanoborohydride; toluene-4-sulfonic acid; In toluene; acetonitrile;

DOI:10.1021/ja108258d

Reference yield:

4-benzyloxy-3-methoxyacetophenone (1835-11-6) → 2-(5-methoxy-2-nitro-4-propargyloxy-α-methylbenzyloxy)ethanol (1260586-86-4)

Guidance literature:

Multi-step reaction with 5 steps

1: nitric acid; acetic acid

2: trifluoroacetic acid

3: potassium carbonate / N,N-dimethyl-formamide / 50 °C

4: toluene-4-sulfonic acid / toluene / 18 h / Reflux

5: titanium tetrachloride; sodium cyanoborohydride / acetonitrile / Cooling with ice; Inert atmosphere

With nitric acid; titanium tetrachloride; sodium cyanoborohydride; potassium carbonate; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid; In N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1021/ja108258d

upstream raw materials:

1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one

2-methyl-2-(5-methoxy-2-nitro-4-propargyloxyphenyl)-1,3-dioxolane

4-benzyloxy-3-methoxyacetophenone

1-(3-methoxy-4-hydroxyphenyl)ethanone

Downstream raw materials:

C₆₅H₉₄N₂O₁₈