(5-{5-[5-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-pyrrol-3-ylcarbamoyl}-1-methyl-1H-pyrrol-3-yl)-carbamic acid tert-butyl ester

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Chemical Name:(5-{5-[5-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-pyrrol-3-ylcarbamoyl}-1-methyl-1H-pyrrol-3-yl)-carbamic acid tert-butyl ester
CAS No.:292069-89-7
Molecular Formula:C₂₈H₄₀N₈O₅
Molecular Weight:568.676
Hs Code.:

(5-{5-[5-(3-dimethylamino-propylcarbamoyl)-1-methyl-1<i>H</i>-pyrrol-3-ylcarbamoyl]-1-methyl-1<i>H</i>-pyrrol-3-ylcarbamoyl}-1-methyl-1<i>H</i>-pyrrol-3-yl)-carbamic acid <i>tert</i>-butyl ester

Synonyms:(5-{5-[5-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-pyrrol-3-ylcarbamoyl}-1-methyl-1H-pyrrol-3-yl)-carbamic acid tert-butyl ester

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Chemical Property of (5-{5-[5-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-pyrrol-3-ylcarbamoyl}-1-methyl-1H-pyrrol-3-yl)-carbamic acid tert-butyl ester

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Technology Process of (5-{5-[5-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-pyrrol-3-ylcarbamoyl}-1-methyl-1H-pyrrol-3-yl)-carbamic acid tert-butyl ester

There total 1 articles about (5-{5-[5-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-pyrrol-3-ylcarbamoyl}-1-methyl-1H-pyrrol-3-yl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77716-11-1
4-[(tert-butoxycarbonyl)amino]-1-methyl-1H-pyrrole-2-carboxylic acid

: 292069-89-7
(5-{5-[5-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-pyrrol-3-ylcarbamoyl}-1-methyl-1H-pyrrol-3-yl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4.3 mg / EDCI; DMAP / dimethylformamide / 16 h / 25 °C

2.1: 98 percent / aq. LiOH / tetrahydrofuran; methanol / 8 h / 60 °C

3.1: EDCI; DMAP / dimethylformamide / 1 h / 25 °C

3.2: 68 percent / dimethylformamide / 13 h / 25 °C

With dmap; lithium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/ja994192d

Reference yield:

: 292069-89-7
(5-{5-[5-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-pyrrol-3-ylcarbamoyl}-1-methyl-1H-pyrrol-3-yl)-carbamic acid tert-butyl ester

: C₃₅H₄₅N₉O₈

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / diethyl ether / 5 h / 20 °C

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h

3: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 18 h

With hydrogenchloride; lithium hydroxide monohydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;

Reference yield:

: 292069-89-7
(5-{5-[5-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-pyrrol-3-ylcarbamoyl}-1-methyl-1H-pyrrol-3-yl)-carbamic acid tert-butyl ester

: C₄₀H₅₀N₁₂O₉

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / diethyl ether / 5 h / 20 °C

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 20 °C

5: lithium hydroxide / tetrahydrofuran; methanol / 20 °C

6: palladium 10% on activated carbon; hydrogen / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;