(2R,3R,4R)-2,4-bis(methoxymethoxy)-4-(3,4-dimethoxyphenyl)-3-pivaloyloxymethylbutanal

Base Information

Chemical Name:(2R,3R,4R)-2,4-bis(methoxymethoxy)-4-(3,4-dimethoxyphenyl)-3-pivaloyloxymethylbutanal
CAS No.:367909-86-2
Molecular Formula:C₂₂H₃₄O₉
Molecular Weight:442.507
Hs Code.:

Synonyms:(2R,3R,4R)-2,4-bis(methoxymethoxy)-4-(3,4-dimethoxyphenyl)-3-pivaloyloxymethylbutanal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R,4R)-2,4-bis(methoxymethoxy)-4-(3,4-dimethoxyphenyl)-3-pivaloyloxymethylbutanal

Chemical Property:

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Technology Process of (2R,3R,4R)-2,4-bis(methoxymethoxy)-4-(3,4-dimethoxyphenyl)-3-pivaloyloxymethylbutanal

There total 7 articles about (2R,3R,4R)-2,4-bis(methoxymethoxy)-4-(3,4-dimethoxyphenyl)-3-pivaloyloxymethylbutanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 367909-85-1
(2S,3R,4R,5R)-3,5-bis(methoxymethoxy)-5-(3,4-dimethoxyphenyl)-4-pivaloyloxymethyl-1,2-pentanediol

: 367909-86-2
(2R,3R,4R)-2,4-bis(methoxymethoxy)-4-(3,4-dimethoxyphenyl)-3-pivaloyloxymethylbutanal

Guidance literature:: With sodium periodate; In methanol; at 20 ℃; for 3h;
DOI:10.1271/bbb.65.1559

Reference yield:

: 3282-30-2
pivaloyl chloride

: 367909-86-2
(2R,3R,4R)-2,4-bis(methoxymethoxy)-4-(3,4-dimethoxyphenyl)-3-pivaloyloxymethylbutanal

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 1 h / 20 °C

2: 80 percent / PPTS / methanol / 3 h / Heating

3: 89 percent / NaIO₄ / methanol / 3 h / 20 °C

With pyridine; sodium periodate; pyridinium p-toluenesulfonate; In methanol;
DOI:10.1271/bbb.65.1559

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 367909-86-2
(2R,3R,4R)-2,4-bis(methoxymethoxy)-4-(3,4-dimethoxyphenyl)-3-pivaloyloxymethylbutanal

Guidance literature:: Multi-step reaction with 6 steps

1: LDA / tetrahydrofuran / 1 h / -75 °C

2: 81 percent / (i-Pr)2NH / CH₂Cl₂ / 3 h / 20 °C

3: LiAlH₄ / tetrahydrofuran / 0.5 h / 20 °C

4: pyridine / 1 h / 20 °C

5: 80 percent / PPTS / methanol / 3 h / Heating

6: 89 percent / NaIO₄ / methanol / 3 h / 20 °C

With pyridine; sodium periodate; lithium aluminium tetrahydride; pyridinium p-toluenesulfonate; diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1271/bbb.65.1559