6-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-5-(2H-tetrazol-5-ylmethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole

Base Information

Chemical Name:6-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-5-(2H-tetrazol-5-ylmethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole
CAS No.:886979-52-8
Molecular Formula:C₂₈H₃₃N₇O₄SSi
Molecular Weight:591.766
Hs Code.:

Synonyms:6-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-5-(2H-tetrazol-5-ylmethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole

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Chemical Property of 6-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-5-(2H-tetrazol-5-ylmethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole

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Technology Process of 6-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-5-(2H-tetrazol-5-ylmethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole

There total 2 articles about 6-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-5-(2H-tetrazol-5-ylmethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 886979-22-2
(5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)acetonitrile

: 886979-23-3
(6-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl)acetonitrile

: 886979-51-7
5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-6-(2H-tetrazol-5-ylmethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole

: 886979-52-8
6-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-5-(2H-tetrazol-5-ylmethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole

Guidance literature:: With trimethylsilylazide; di(n-butyl)tin oxide; In toluene; Heating / reflux;

Reference yield:

: 773837-37-9
sodium cyanide

: 886976-80-3
methyl 5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1H-benzimidazole-6-carboxylate

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 886979-51-7
5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-6-(2H-tetrazol-5-ylmethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole

: 886979-52-8
6-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-5-(2H-tetrazol-5-ylmethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole

Guidance literature:: methyl 5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1H-benzimidazole-6-carboxylate; (2-trimethylethylsilylethoxy)methyl chloride; With sodium hydride; In N,N-dimethyl-formamide; paraffin oil; at 20 ℃; for 0.5h;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

sodium cyanide; Further stages;
DOI:10.1016/j.bmc.2009.05.037