6-[2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]nicotinonitrile

Base Information

Chemical Name:6-[2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]nicotinonitrile
CAS No.:1378037-57-0
Molecular Formula:C₁₈H₁₀Cl₂N₆
Molecular Weight:381.224
Hs Code.:

Synonyms:6-[2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]nicotinonitrile

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Chemical Property of 6-[2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]nicotinonitrile

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Technology Process of 6-[2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]nicotinonitrile

There total 6 articles about 6-[2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 4214-73-7
6-aminonicotinonitrile

: 1378039-20-3
4-chloro-2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridine

: 1378037-57-0
6-[2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]nicotinonitrile

Guidance literature:: 6-aminonicotinonitrile; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 150 ℃; for 0.25h; Sealed vial; Inert atmosphere; Microwave irradiation;

4-chloro-2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridine;

Reference yield:

: 1378039-23-6
[1-(4-azidopyridin-3-yl)meth-(E)-ylidene]-(2,6-dichlorophenyl)amine

: 1378037-57-0
6-[2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]nicotinonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 18 h / 105 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3: tetrabutyl-ammonium chloride / trichlorophosphate / 5 h / 20 - 80 °C

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 150 °C / Sealed vial; Inert atmosphere; Microwave irradiation

With tetrabutyl-ammonium chloride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil; trichlorophosphate;

Reference yield:

: 114077-82-6
4-chloronicotinaldehyde

: 1378037-57-0
6-[2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]nicotinonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: sodium azide / N,N-dimethyl-formamide / 18 h

2: triethylamine; titanium tetrachloride / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

3: toluene / 18 h / 105 °C

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

5: tetrabutyl-ammonium chloride / trichlorophosphate / 5 h / 20 - 80 °C

6: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 150 °C / Sealed vial; Inert atmosphere; Microwave irradiation

With sodium azide; tetrabutyl-ammonium chloride; titanium tetrachloride; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil; trichlorophosphate;