Technology Process of Methanesulfonic acid 1-[2-(2-methyl-[1,3]dithiolan-2-yl)-ethyl]-2-p-tolyl-propyl ester
There total 6 articles about Methanesulfonic acid 1-[2-(2-methyl-[1,3]dithiolan-2-yl)-ethyl]-2-p-tolyl-propyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) n-butyl-lithium / 1.) ether, 4 h, -15 deg C, 2.) 2 h, -15 deg C
2: 69.3 percent / glacial acetic acid, 20percent H2SO4 / H2O / 2 h / 120 °C
3: 82.3 percent / boron trifluoride etherate / CH2Cl2 / 2 h / Ambient temperature
4: 1.) sodium hydride / 1,2-dimethoxy-ethane / 1.) 0.5 h, 70 deg, 2.) 1 h, reflux
5: 79.5 percent / sodium borohydride / methanol / 1 h / Ambient temperature
6: 44.3 percent / pyridine / 8 h / Ambient temperature
With
sodium tetrahydroborate; n-butyllithium; sulfuric acid; boron trifluoride diethyl etherate; sodium hydride; acetic acid;
In
pyridine; methanol; 1,2-dimethoxyethane; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 69.3 percent / glacial acetic acid, 20percent H2SO4 / H2O / 2 h / 120 °C
2: 82.3 percent / boron trifluoride etherate / CH2Cl2 / 2 h / Ambient temperature
3: 1.) sodium hydride / 1,2-dimethoxy-ethane / 1.) 0.5 h, 70 deg, 2.) 1 h, reflux
4: 79.5 percent / sodium borohydride / methanol / 1 h / Ambient temperature
5: 44.3 percent / pyridine / 8 h / Ambient temperature
With
sodium tetrahydroborate; sulfuric acid; boron trifluoride diethyl etherate; sodium hydride; acetic acid;
In
pyridine; methanol; 1,2-dimethoxyethane; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 82.3 percent / boron trifluoride etherate / CH2Cl2 / 2 h / Ambient temperature
2: 1.) sodium hydride / 1,2-dimethoxy-ethane / 1.) 0.5 h, 70 deg, 2.) 1 h, reflux
3: 79.5 percent / sodium borohydride / methanol / 1 h / Ambient temperature
4: 44.3 percent / pyridine / 8 h / Ambient temperature
With
sodium tetrahydroborate; boron trifluoride diethyl etherate; sodium hydride;
In
pyridine; methanol; 1,2-dimethoxyethane; dichloromethane;