tert-butyl (3R)-3-({benzyl[(benzyloxy)carbonyl]amino}methyl)-4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-4-oxobutanoate

Base Information

Chemical Name:tert-butyl (3R)-3-({benzyl[(benzyloxy)carbonyl]amino}methyl)-4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-4-oxobutanoate
CAS No.:252919-10-1
Molecular Formula:C₃₄H₃₈N₂O₇
Molecular Weight:586.685
Hs Code.:

Synonyms:tert-butyl (3R)-3-({benzyl[(benzyloxy)carbonyl]amino}methyl)-4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-4-oxobutanoate

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Chemical Property of tert-butyl (3R)-3-({benzyl[(benzyloxy)carbonyl]amino}methyl)-4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-4-oxobutanoate

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Technology Process of tert-butyl (3R)-3-({benzyl[(benzyloxy)carbonyl]amino}methyl)-4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-4-oxobutanoate

There total 6 articles about tert-butyl (3R)-3-({benzyl[(benzyloxy)carbonyl]amino}methyl)-4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 252919-09-8
benzyl benzyl{3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}carbamate

: 252919-10-1
tert-butyl (3R)-3-({benzyl[(benzyloxy)carbonyl]amino}methyl)-4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-4-oxobutanoate

Guidance literature:: benzyl benzyl{3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}carbamate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; at -30 ℃; for 5h; Further stages.;
DOI:10.1021/jo016086b

Reference yield:

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 252919-10-1
tert-butyl (3R)-3-({benzyl[(benzyloxy)carbonyl]amino}methyl)-4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-4-oxobutanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / NaH / tetrahydrofuran; dimethylformamide / 20 °C

2.1: Et₃N / tetrahydrofuran / 1 h / -30 °C

3.1: 55.4 g / LiCl / tetrahydrofuran / 20 °C

4.1: LDA / tetrahydrofuran / 1 h / -78 °C

4.2: 75 percent / tetrahydrofuran / 5 h / -30 °C

With sodium hydride; triethylamine; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo016086b

Reference yield:

: 40217-17-2,90719-32-7,120574-96-1,102029-44-7
(R)-4-(phenylmethyl)-2-oxazolidinone

: 252919-10-1
tert-butyl (3R)-3-({benzyl[(benzyloxy)carbonyl]amino}methyl)-4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-4-oxobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 55.4 g / LiCl / tetrahydrofuran / 20 °C

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: 75 percent / tetrahydrofuran / 5 h / -30 °C

With lithium chloride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jo016086b