benzyl (3R,4S)-3-[(3,6-diethylpyrazin-2-yl)amino]-4-hydroxypyrrolidine-1-carboxylate

Base Information

Chemical Name:benzyl (3R,4S)-3-[(3,6-diethylpyrazin-2-yl)amino]-4-hydroxypyrrolidine-1-carboxylate
CAS No.:535936-23-3
Molecular Formula:C₂₀H₂₆N₄O₃
Molecular Weight:370.451
Hs Code.:

Synonyms:benzyl (3R,4S)-3-[(3,6-diethylpyrazin-2-yl)amino]-4-hydroxypyrrolidine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (3R,4S)-3-[(3,6-diethylpyrazin-2-yl)amino]-4-hydroxypyrrolidine-1-carboxylate

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Technology Process of benzyl (3R,4S)-3-[(3,6-diethylpyrazin-2-yl)amino]-4-hydroxypyrrolidine-1-carboxylate

There total 2 articles about benzyl (3R,4S)-3-[(3,6-diethylpyrazin-2-yl)amino]-4-hydroxypyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 535936-21-1
benzyl (3 R,4S)-3-amino-4-hydroxypyrrolidine-1-carboxylate

: 67714-53-8
3-chloro-2,5-diethylpyrazine

: 535936-23-3
benzyl (3R,4S)-3-[(3,6-diethylpyrazin-2-yl)amino]-4-hydroxypyrrolidine-1-carboxylate

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos; In 1,2-dimethoxyethane; at 80 ℃; for 20h;

Reference yield:

: 535936-21-1
benzyl (3 R,4S)-3-amino-4-hydroxypyrrolidine-1-carboxylate

: 213697-53-1
DavePhos

: 535936-23-3
benzyl (3R,4S)-3-[(3,6-diethylpyrazin-2-yl)amino]-4-hydroxypyrrolidine-1-carboxylate

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,2-dimethoxyethane; n-heptane; ethyl acetate;

Reference yield: 77.0%

: 535936-23-3
benzyl (3R,4S)-3-[(3,6-diethylpyrazin-2-yl)amino]-4-hydroxypyrrolidine-1-carboxylate

: 75-03-6
ethyl iodide

: benzyl (3R,4S)-3-[(3,6-diethylpyrazin-2-yl)amino]-4-ethoxypyrrolidine-1-carboxylate

Guidance literature:: benzyl (3R,4S)-3-[(3,6-diethylpyrazin-2-yl)amino]-4-hydroxypyrrolidine-1-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

ethyl iodide; In N,N-dimethyl-formamide; for 2h;