4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide hydrochloride

Base Information

Chemical Name:4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide hydrochloride
CAS No.:1260487-52-2
Molecular Formula:C₁₉H₁₅F₅N₆O₂*ClH
Molecular Weight:490.82
Hs Code.:

Synonyms:4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide hydrochloride

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Chemical Property of 4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide hydrochloride

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Technology Process of 4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide hydrochloride

There total 3 articles about 4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1260487-53-3
4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide

: 1260487-52-2
4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; ethanol; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

: 1260487-54-4
4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-(2,4-dimethoxybenzylamide)

: 1260487-52-2
4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 14 h / Reflux

2: hydrogenchloride / diethyl ether; ethanol / 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; toluene-4-sulfonic acid; In diethyl ether; ethanol;

Reference yield:

: 210992-28-2
3-amino-5-fluoro-benzonitrile

: 1260487-52-2
4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere; Reflux

1.2: 2 h

2.1: diisobutylaluminium hydride / hexane; tetrahydrofuran / 15 h / -2 - 20 °C / Inert atmosphere

3.1: magnesium sulfate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 14 h / 20 °C / Inert atmosphere; Reflux

3.2: 72 h / 20 - 25 °C

4.1: toluene-4-sulfonic acid / 14 h / Reflux

5.1: hydrogenchloride / diethyl ether; ethanol / 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; diisobutylaluminium hydride; magnesium sulfate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; ethanol; hexane;