4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide

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Chemical Name:4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide
CAS No.:1260487-53-3
Molecular Formula:C₁₉H₁₅F₅N₆O₂
Molecular Weight:454.359
Hs Code.:

Synonyms:4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide

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Chemical Property of 4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide

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Technology Process of 4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide

There total 2 articles about 4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1260487-54-4
4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-(2,4-dimethoxybenzylamide)

: 1260487-53-3
4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide

Guidance literature:: 4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-(2,4-dimethoxybenzylamide); With toluene-4-sulfonic acid; for 14h; Reflux;

With sodium hydroxide; In water;

Reference yield:

: 210992-28-2
3-amino-5-fluoro-benzonitrile

: 1260487-53-3
4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere; Reflux

1.2: 2 h

2.1: diisobutylaluminium hydride / hexane; tetrahydrofuran / 15 h / -2 - 20 °C / Inert atmosphere

3.1: magnesium sulfate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 14 h / 20 °C / Inert atmosphere; Reflux

3.2: 72 h / 20 - 25 °C

4.1: toluene-4-sulfonic acid / 14 h / Reflux

With diisobutylaluminium hydride; magnesium sulfate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane;