1-ethyl-2-[({4-[(4-fluorophenyl)oxy]phenyl}methyl)thio]-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

Base Information

Chemical Name:1-ethyl-2-[({4-[(4-fluorophenyl)oxy]phenyl}methyl)thio]-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone
CAS No.:1380427-35-9
Molecular Formula:C₂₅H₂₃FN₄O₃S
Molecular Weight:478.547
Hs Code.:

Synonyms:1-ethyl-2-[({4-[(4-fluorophenyl)oxy]phenyl}methyl)thio]-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

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Chemical Property of 1-ethyl-2-[({4-[(4-fluorophenyl)oxy]phenyl}methyl)thio]-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

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Technology Process of 1-ethyl-2-[({4-[(4-fluorophenyl)oxy]phenyl}methyl)thio]-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

There total 7 articles about 1-ethyl-2-[({4-[(4-fluorophenyl)oxy]phenyl}methyl)thio]-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.64%

: 1380427-33-7
2-((4-(4-fluorophenoxy)benzyl)thio)-5-((2-methoxypyrimidin-5-yl)methyl)pyrimidin-4(1H)-one

: 75-03-6
ethyl iodide

: 1380427-35-9
1-ethyl-2-[({4-[(4-fluorophenyl)oxy]phenyl}methyl)thio]-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 55 ℃; for 2h;

Reference yield:

: 167091-97-6
4-(4'-fluorophenoxy)benzyl chloride

: 1380427-35-9
1-ethyl-2-[({4-[(4-fluorophenyl)oxy]phenyl}methyl)thio]-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropylamine / dichloromethane / 60 °C

2: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 55 °C

With diisopropylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 167091-96-5
4-(4'-fluorophenoxy)benzylalcohol

: 1380427-35-9
1-ethyl-2-[({4-[(4-fluorophenyl)oxy]phenyl}methyl)thio]-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; thionyl chloride / dichloromethane / 0 - 20 °C

2: diisopropylamine / dichloromethane / 60 °C

3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 55 °C

With pyridine; thionyl chloride; diisopropylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane;