(2S,2'S)-2-benzyl-3-(N-phenylmethoxycarbonyl-pyrrolidine-2'-yl)propanoic acid ethyl ester

Base Information

Chemical Name:(2S,2'S)-2-benzyl-3-(N-phenylmethoxycarbonyl-pyrrolidine-2'-yl)propanoic acid ethyl ester
CAS No.:777863-54-4
Molecular Formula:C₂₄H₂₉NO₄
Molecular Weight:395.499
Hs Code.:

Synonyms:(2S,2'S)-2-benzyl-3-(N-phenylmethoxycarbonyl-pyrrolidine-2'-yl)propanoic acid ethyl ester

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Chemical Property of (2S,2'S)-2-benzyl-3-(N-phenylmethoxycarbonyl-pyrrolidine-2'-yl)propanoic acid ethyl ester

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Technology Process of (2S,2'S)-2-benzyl-3-(N-phenylmethoxycarbonyl-pyrrolidine-2'-yl)propanoic acid ethyl ester

There total 4 articles about (2S,2'S)-2-benzyl-3-(N-phenylmethoxycarbonyl-pyrrolidine-2'-yl)propanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 100-39-0
benzyl bromide

: 777863-52-2
(S)-2-(2-Ethoxycarbonyl-ethyl)-pyrrolidine-1-carboxylic acid benzyl ester

: (2R,2'S)-2-benzyl-3-(N-phenylmethoxycarbonyl-pyrrolidine-2'-yl)propanoic acid ethyl ester

: 777863-54-4
(2S,2'S)-2-benzyl-3-(N-phenylmethoxycarbonyl-pyrrolidine-2'-yl)propanoic acid ethyl ester

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;
DOI:10.1081/SCC-200028616

Reference yield:

: 65985-73-1
(S)-2-(3-Diazo-2-oxo-propyl)-pyrrolidin-1-carbonsaeure-benzylester

: 777863-54-4
(2S,2'S)-2-benzyl-3-(N-phenylmethoxycarbonyl-pyrrolidine-2'-yl)propanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: silver oxide; TEA

2: 86 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

With TEA; silver(l) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1: Wolff rearrangement;
DOI:10.1081/SCC-200028616

Reference yield:

: 56633-73-9
(S)-2-(1-((benzyloxy)carbonyl)pyrrolidine-2-yl)acetic acid

: 777863-54-4
(2S,2'S)-2-benzyl-3-(N-phenylmethoxycarbonyl-pyrrolidine-2'-yl)propanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether

2: diethyl ether

3: silver oxide; TEA

4: 86 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

With TEA; silver(l) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; 3: Wolff rearrangement;
DOI:10.1081/SCC-200028616